Cellular function requires coordination between different organelles and metabolic cues.
Mitochondria and lysosomes are essential for cellular metabolism as major contributors of …

In the last decades, lysosomes and mitochondria were considered distinct and physically
separated organelles involved in different cellular functions. While lysosomes were thought …

The function of mitochondria and lysosomes has classically been studied separately.
However, evidence has now emerged of intense crosstalk between these two organelles …

Mitochondria are key cellular signaling platforms, affecting fundamental processes such as
cell proliferation, differentiation and death. However, it remains unclear how mitochondrial …

Efforts to understand how mitochondrial dysfunction contributes to neurodegeneration have
primarily focussed on the role of mitochondria in neuronal energy metabolism. However …

Mitochondria are the powerhouses for the cell, consuming oxygen to generate sufficient
energy for the maintenance of normal cellular processes. However, a deleterious …

Mitochondria represent the major bioenergetic hub coordinating cellular and organismal
homeostasis. The underlying causes of many pathologies tormenting humans converge on …

Cellular organelles are not static but show dynamism—a property that is likely relevant for
their function. In addition, they interact with other organelles in a highly dynamic manner. In …

Mitochondria are crucial organelles that play a central role in various cell signaling and
metabolic pathways. A healthy mitochondrial population is maintained through a series of …

Mitochondria perform diverse yet interconnected functions, producing ATP and many
biosynthetic intermediates while also contributing to cellular stress responses such as …