PPARs: fatty acid sensors controlling metabolism

L la Cour Poulsen, M Siersbæk, S Mandrup - Seminars in cell & …, 2012 - Elsevier
The peroxisome proliferator activated receptors (PPARs) are nuclear receptors that play key
roles in the regulation of lipid metabolism, inflammation, cellular growth, and differentiation …

PPARs: transcriptional effectors of fatty acids and their derivatives

AK Hihi, L Michalik, W Wahli - Cellular and Molecular Life Sciences, 2002 - Springer
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that
mediate the effects of fatty acids and their derivatives at the transcriptional level. These …

[HTML][HTML] PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation

T Varga, Z Czimmerer, L Nagy - … et Biophysica Acta (BBA)-Molecular Basis …, 2011 - Elsevier
Cells are constantly exposed to a large variety of lipids. Traditionally, these molecules were
thought to serve as simple energy storing molecules. More recently it has been realized that …

Lipid sensing and lipid sensors: peroxisome proliferator-activated receptors as sensors of fatty acids and derivatives

PA Grimaldi - Cellular and Molecular Life Sciences, 2007 - Springer
Lipid homeostasis requires a strict balance between lipid intake and consumption. This
balance is controlled by different systems that regulate food intake, energy storage and …

Peroxisome proliferator-activated receptors and the regulation of mammalian lipid metabolism

SA Smith - Biochemical Society Transactions, 2002 - portlandpress.com
Peroxisome proliferator-activated receptors (PPARs) are members of the superfamily of
ligand-activated nuclear transcription factors. Three PPAR subtypes, PPARα, PPARδ …

From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions

JN Feige, L Gelman, L Michalik, B Desvergne… - Progress in lipid …, 2006 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) compose a family of three nuclear
receptors which act as lipid sensors to modulate gene expression. As such, PPARs are …

Peroxisome proliferator‐activated receptor alpha target genes

M Rakhshandehroo, B Knoch, M Müller… - PPAR …, 2010 - Wiley Online Library
The peroxisome proliferator‐activated receptor alpha (PPARα) is a ligand‐activated
transcription factor involved in the regulation of a variety of processes, ranging from …

Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice

IP Torra, G Chinetti, C Duval, JC Fruchart… - Current Opinion in …, 2001 - journals.lww.com
Peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors
that control energy homeostasis through genomic actions. Over the past few years …

The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity

P Ferré - Diabetes, 2004 - Am Diabetes Assoc
Peroxisome proliferator-activated receptors (PPARs) are transcription factors belonging to
the superfamily of nuclear receptors. Three isoforms (α, δ, and γ) have been described. They …

The peroxisome proliferator-activated receptor N-terminal domain controls isotype-selective gene expression and adipogenesis

S Hummasti, P Tontonoz - Molecular endocrinology, 2006 - academic.oup.com
Peroxisome proliferator-activated receptors (PPARγ, PPARα, and PPARδ) are important
regulators of lipid metabolism. Although they share significant structural similarity, the …