PPARs: fatty acid sensors controlling metabolism
L la Cour Poulsen, M Siersbæk, S Mandrup - Seminars in cell & …, 2012 - Elsevier
The peroxisome proliferator activated receptors (PPARs) are nuclear receptors that play key
roles in the regulation of lipid metabolism, inflammation, cellular growth, and differentiation …
roles in the regulation of lipid metabolism, inflammation, cellular growth, and differentiation …
PPARs: transcriptional effectors of fatty acids and their derivatives
AK Hihi, L Michalik, W Wahli - Cellular and Molecular Life Sciences, 2002 - Springer
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that
mediate the effects of fatty acids and their derivatives at the transcriptional level. These …
mediate the effects of fatty acids and their derivatives at the transcriptional level. These …
[HTML][HTML] PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation
Cells are constantly exposed to a large variety of lipids. Traditionally, these molecules were
thought to serve as simple energy storing molecules. More recently it has been realized that …
thought to serve as simple energy storing molecules. More recently it has been realized that …
Lipid sensing and lipid sensors: peroxisome proliferator-activated receptors as sensors of fatty acids and derivatives
PA Grimaldi - Cellular and Molecular Life Sciences, 2007 - Springer
Lipid homeostasis requires a strict balance between lipid intake and consumption. This
balance is controlled by different systems that regulate food intake, energy storage and …
balance is controlled by different systems that regulate food intake, energy storage and …
Peroxisome proliferator-activated receptors and the regulation of mammalian lipid metabolism
SA Smith - Biochemical Society Transactions, 2002 - portlandpress.com
Peroxisome proliferator-activated receptors (PPARs) are members of the superfamily of
ligand-activated nuclear transcription factors. Three PPAR subtypes, PPARα, PPARδ …
ligand-activated nuclear transcription factors. Three PPAR subtypes, PPARα, PPARδ …
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions
JN Feige, L Gelman, L Michalik, B Desvergne… - Progress in lipid …, 2006 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) compose a family of three nuclear
receptors which act as lipid sensors to modulate gene expression. As such, PPARs are …
receptors which act as lipid sensors to modulate gene expression. As such, PPARs are …
Peroxisome proliferator‐activated receptor alpha target genes
The peroxisome proliferator‐activated receptor alpha (PPARα) is a ligand‐activated
transcription factor involved in the regulation of a variety of processes, ranging from …
transcription factor involved in the regulation of a variety of processes, ranging from …
Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice
Peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors
that control energy homeostasis through genomic actions. Over the past few years …
that control energy homeostasis through genomic actions. Over the past few years …
The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity
P Ferré - Diabetes, 2004 - Am Diabetes Assoc
Peroxisome proliferator-activated receptors (PPARs) are transcription factors belonging to
the superfamily of nuclear receptors. Three isoforms (α, δ, and γ) have been described. They …
the superfamily of nuclear receptors. Three isoforms (α, δ, and γ) have been described. They …
The peroxisome proliferator-activated receptor N-terminal domain controls isotype-selective gene expression and adipogenesis
S Hummasti, P Tontonoz - Molecular endocrinology, 2006 - academic.oup.com
Peroxisome proliferator-activated receptors (PPARγ, PPARα, and PPARδ) are important
regulators of lipid metabolism. Although they share significant structural similarity, the …
regulators of lipid metabolism. Although they share significant structural similarity, the …