Currently available antidepressants used to treat major depressive disorder (MDD)
unfortunately often take weeks to months to achieve their full effects, commonly resulting in …

Depression is a serious and burdensome illness. Although selective serotonin reuptake
inhibitors (SSRIs) have improved safety and tolerability of antidepressant treatment efficacy …

Traditional pharmacological treatments for depression have a delayed therapeutic onset,
ranging from several weeks to months, and there is a high percentage of individuals who …

Objective: Current therapeutics of depression are similar in their time to antidepressant
action and often take weeks to months to achieve response and remission, which commonly …

Although antidepressant medications are effective in approximately 70% of patients with
major depressive disorder, they have a delayed onset of therapeutic effect. This latency is …

OBJECTIVE: The primary objective of this article is to review the literature regarding the
speed of response to antidepressant drugs and potential strategies to accelerate the …

The question of when antidepressant drugs (AD) initiate significant clinical actions in
depressed patients is still unsettled. Findings from early studies on whether there is a lag in …

There is still considerable controversy about the onset and time course of improvement with
antidepressants in the treatment of major depressive disorder. Previous studies suggested a …

The onset of action of antidepressant drugs was investigated on the basis of two
independent, multicenter, double-blind studies, comparing amitriptyline (N= 120) …

Major depression is a highly prevalent disorder and is predicted to be the second leading
cause of disease burden by 2020. Although many antidepressant drugs are currently …