Single-cell all-optical coherence elastography with optical tweezers

MA Sirotin, MN Romodina, EV Lyubin… - Biomedical Optics …, 2022 - opg.optica.org
The elastic properties of cells are important for many of their functions, however the
development of label free noninvasive cellular elastography method is a challenging topic …

Ultrahigh-resolution optical coherence elastography through a micro-endoscope: towards in vivo imaging of cellular-scale mechanics

Q Fang, A Curatolo, P Wijesinghe, YL Yeow… - Biomedical optics …, 2017 - opg.optica.org
In this paper, we describe a technique capable of visualizing mechanical properties at the
cellular scale deep in living tissue, by incorporating a gradient-index (GRIN)-lens micro …

Ultrafast imaging of cell elasticity with optical microelastography

P Grasland-Mongrain, A Zorgani… - Proceedings of the …, 2018 - National Acad Sciences
Elasticity is a fundamental cellular property that is related to the anatomy, functionality, and
pathological state of cells and tissues. However, current techniques based on cell …

The emergence of optical elastography in biomedicine

BF Kennedy, P Wijesinghe, DD Sampson - Nature Photonics, 2017 - nature.com
Optical elastography, the use of optics to characterize and map the mechanical properties of
biological tissue, involves measuring the deformation of tissue in response to a load. Such …

[HTML][HTML] Debiased ambient vibrations optical coherence elastography to profile cell, organoid and tissue mechanical properties

JH Mason, L Luo, Y Reinwald, M Taffetani… - Communications …, 2023 - nature.com
The role of the mechanical environment in defining tissue function, development and growth
has been shown to be fundamental. Assessment of the changes in stiffness of tissue …

Ultrahigh-resolution optical coherence elastography

A Curatolo, M Villiger, D Lorenser, P Wijesinghe… - Optics letters, 2016 - opg.optica.org
Visualizing stiffness within the local tissue environment at the cellular and subcellular level
promises to provide insight into the genesis and progression of disease. In this Letter, we …

Subcellular mechano-microscopy: high resolution three-dimensional elasticity mapping using optical coherence microscopy

A Mowla, J Li, MS Hepburn, S Maher, L Chin… - Optics Letters, 2022 - opg.optica.org
The importance of cellular-scale mechanical properties is well-established, yet it is
challenging to map subcellular elasticity in three dimensions. We present subcellular …

In situ stress estimation in quantitative micro-elastography

F Navaeipour, MS Hepburn, J Li, KL Metzner… - Biomedical Optics …, 2024 - opg.optica.org
In quantitative micro-elastography (QME), a pre-characterized compliant layer with a known
stress-strain curve is utilized to map stress at the sample surface. However, differences in …

Characterizing single suspended cells by optorheology

F Wottawah, S Schinkinger, B Lincoln, S Ebert… - Acta biomaterialia, 2005 - Elsevier
The measurement of the mechanical properties of individual cells has received much
attention in recent years. In this paper we describe the application of optically induced forces …

Portable optical coherence elastography system with flexible and phase stable common path optical fiber probe

A Parmar, G Sharma, S Sharma, K Singh - IEEE Access, 2021 - ieeexplore.ieee.org
Biomechanical properties drive the functioning of cells and tissue. Measurement of such
properties in the clinic is quite challenging, however. Optical coherence elastography is an …