Placental exosome-mediated Bta-miR-499-Lin28B/let-7 axis regulates inflammatory bias during early pregnancy

G Zhao, C Yang, J Yang, P Liu, K Jiang… - Cell death & …, 2018 - nature.com
Abnormal inflammatory bias in the maternal-fetal interface leads to reproductive failure in
mammals. Placental exosomes are involved in maternal-fetal communication during …

Murine trophoblast-derived and pregnancy-associated exosome-enriched extracellular vesicle microRNAs: Implications for placenta driven effects on maternal …

AL Stefanski, N Martinez, LK Peterson, TJ Callahan… - PloS one, 2019 - journals.plos.org
The role of extracellular vesicles (EVs), specifically exosomes, in intercellular
communication likely plays a key role in placental orchestration of pregnancy and maternal …

Placental trophoblast cell-derived exosomal microRNA-1290 promotes the interaction between endometrium and embryo by targeting LHX6

S Shi, Q Tan, J Liang, D Cao, S Wang, J Liang… - … Therapy-Nucleic Acids, 2021 - cell.com
Communication between the maternal uterus and the embryo is vital for a successful
pregnancy. Exosomes, subtypes of extracellular vesicles comprising many bioactive factors …

Transfer of miR-15a-5p by placental exosomes promotes pre-eclampsia progression by regulating PI3K/AKT signaling pathway via CDK1

Y Wang, X Du, J Wang - Molecular Immunology, 2020 - Elsevier
Preeclampsia (PE) is a systemic complication that occurs after the 20th week of gestation
and is characterized by the onset of hypertension and proteinuria. Dysregulated circulating …

miR-15b-5p promotes expression of proinflammatory cytokines in human placenta by inhibiting Apelin signaling pathway

SM Yadava, A Feng, N Parobchak, B Wang, T Rosen - Placenta, 2021 - Elsevier
Introduction The timing of parturition at end of human gestation may be controlled by fetal
signals. The signaling molecules contributing to activation of human labor may be mediated …

Cross talk: trafficking and functional impact of maternal exosomes at the feto-maternal interface under normal and pathologic states

OAG Tantengco, E Radnaa, H Shahin… - Biology of …, 2021 - academic.oup.com
Fetal cell-derived exosomes promote inflammation in uterine and cervical cells to promote
labor and delivery. However, the effect of maternal exosomes on fetal cells is still not known …

The effect of bta-miR-26b in intrauterine extracellular vesicles on maternal immune system during the implantation period

K Nakamura, K Kusama, M Hori, K Imakawa - Biochemical and Biophysical …, 2021 - Elsevier
Extracellular vesicles (EVs) in utero play a role in cellular interactions between endometrium-
conceptuses (embryo plus extraembryonic membranes) during peri-implantation periods …

[HTML][HTML] Insights into extracellular vesicle/exosome and miRNA mediated Bi-directional communication during porcine pregnancy

M Bidarimath, H Lingegowda, JE Miller… - Frontiers in Veterinary …, 2021 - frontiersin.org
Spontaneous fetal loss is one of the most important challenges that commercial pig industry
is still facing in North America. Research over the decade provided significant insights into …

Macrophage exosomes induce placental inflammatory cytokines: a novel mode of maternal–placental messaging

B Holder, T Jones, V Sancho Shimizu, TF Rice… - Traffic, 2016 - Wiley Online Library
During pregnancy, the placenta forms the interface between mother and fetus. Highly
controlled regulation of trans‐placental trafficking is therefore essential for the healthy …

Exosomes released from decidual macrophages deliver miR-153-3p, which inhibits trophoblastic biological behavior in unexplained recurrent spontaneous abortion

X Ying, X Jin, Y Zhu, M Liang, X Chang… - International …, 2020 - Elsevier
Background Spontaneous abortion is a common disease in human pregnancy. Increasing
evidence suggests that proper function of trophoblasts and immune balance of the maternal …