The ischemic etiology of heart failure is an independent prognostic factor associated with
worse long-term outcome. Recent evidence indicates a role for genetic susceptibility to …

Objective To review possible associations reported between genetic variants and the risk,
therapeutic response and prognosis of heart failure. Methods Electronic databases …

Heart failure is a complex clinical syndrome. There is evidence for a genetic contribution to
the pathophysiology of heart failure. Considering the fundamental role of neurohormonal …

The pathogenesis of heart failure involves a complex interaction between genetic and
environmental factors. Genetic factors may influence the susceptibility to the underlying …

Heart failure (HF) is a complex clinical syndrome and is thought to have a genetic basis.
Numerous case–control studies have investigated the association between heart failure and …

It is well appreciated that several neurohormones and signaling cascades are activated that
promote long-term deterioration of cardiac function and structure. Activation of the renin …

Angiotensin II plays an important role in diastolic heart failure (DHF). However, genetic
studies of DHF are scarce in the literature. We hypothesized that RAS genes might be the …

Heart failure (HF) is characterized by neurohormonal activation of the sympathetic nervous
and renin-angiotensin systems. Genetic polymorphisms in these systems could alter the …

Common genetic variants in candidate genes are likely to play a role in susceptibility, and
phenotypic evolution of heart failure (HF), and in the response to a complex influence of …

Little is known about genetics of heart failure with preserved ejection fraction (HFpEF) in part
because of the many comorbidities in this population. To identify single-nucleotide …