Consensus paper: Cerebellum and ageing

A Arleo, M Bareš, JA Bernard, HR Bogoian… - The Cerebellum, 2024 - Springer
Given the key roles of the cerebellum in motor, cognitive, and affective operations and given
the decline of brain functions with aging, cerebellar circuitry is attracting the attention of the …

Moving forward: age effects on the cerebellum underlie cognitive and motor declines

JA Bernard, RD Seidler - Neuroscience & Biobehavioral Reviews, 2014 - Elsevier
Though the cortical contributions to age-related declines in motor and cognitive performance
are well-known, the potential contributions of the cerebellum are less clear. The diverse …

[HTML][HTML] Differential vulnerability of the cerebellum in healthy ageing and Alzheimer's disease

HM Gellersen, X Guell, S Sami - NeuroImage: Clinical, 2021 - Elsevier
Recent findings challenge the prior notion that the cerebellum remains unaffected by
Alzheimer's disease (AD). Yet, it is unclear whether AD exacerbates age-related cerebellar …

Resistance, vulnerability and resilience: a review of the cognitive cerebellum in aging and neurodegenerative diseases

KJ Liang, ES Carlson - Neurobiology of Learning and Memory, 2020 - Elsevier
In the context of neurodegeneration and aging, the cerebellum is an enigma. Genetic
markers of cellular aging in cerebellum accumulate more slowly than in the rest of the brain …

Don't forget the little brain: A framework for incorporating the cerebellum into the understanding of cognitive aging

JA Bernard - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
With the rapidly growing population of older adults, an improved understanding of brain and
cognitive aging is critical, given the impacts on health, independence, and quality of life. To …

Ageing shows a pattern of cerebellar degeneration analogous, but not equal, to that in patients suffering from cerebellar degenerative disease

T Hulst, JN van der Geest, M Thürling, S Goericke… - Neuroimage, 2015 - Elsevier
Ageing generally leads to impairments in cognitive function and the ability to execute and
learn new movements. While the causes of these impairments are often multi-factorial …

Disrupted cortico-cerebellar connectivity in older adults

JA Bernard, SJ Peltier, JL Wiggins, SM Jaeggi… - Neuroimage, 2013 - Elsevier
Healthy aging is marked by declines in a variety of cognitive and motor abilities. A better
understanding of the aging brain may aid in elucidating the neural substrates of these …

The cerebellum shrinks faster than normal ageing in A lzheimer's disease but not in mild cognitive impairment

H Tabatabaei‐Jafari, E Walsh, ME Shaw… - Human brain …, 2017 - Wiley Online Library
Background While acceleration in age‐related cerebral atrophy has been well documented
in Alzheimer's disease, the cerebellar contributions to this effect have not been thoroughly …

[HTML][HTML] Associations of baseline and longitudinal change in cerebellum volume with age-related changes in verbal learning and memory

PC C'iana, AT Shafer, NM Armstrong, Y An, G Erus… - Neuroimage, 2023 - Elsevier
The cerebellum is involved in higher-order cognitive functions, eg, learning and memory,
and is susceptible to age-related atrophy. Yet, the cerebellum's role in age-related cognitive …

[HTML][HTML] Longitudinal analysis of regional cerebellum volumes during normal aging

S Han, Y An, A Carass, JL Prince, SM Resnick - NeuroImage, 2020 - Elsevier
Some cross-sectional studies suggest reduced cerebellar volumes with aging, but there
have been few longitudinal studies of age changes in cerebellar subregions in cognitively …