Over the past decade, researchers have highlighted the importance of mechanical cues of
the metastatic niche such as matrix stiffness, topography, mechanical stresses, and …

Mechanical features of cancer cells emerge as a distinct trait during development and
progression of solid tumors. Herein, we discuss recent key findings regarding the impact of …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Cross-talk between tumor cells and mechanical stress in the tumor microenvironment has
been shown to be involved in carcinogenesis. High mechanical stress in tumors can alter …

The extracellular matrix (ECM) is pivotal in modulating tumor progression. Besides
chemically stimulating tumor cells, it also offers physical support that orchestrates the …

The cellular microenvironment plays an important role in regulating cancer progress. Cancer
can physically and chemically remodel its surrounding extracellular matrix (ECM). Critical …

Mechanosensing is increasingly recognised as important for tumour progression. Tumours
become stiff and the forces that normally balance in the healthy organism break down and …

Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-
related death. Metastatic disease or the movement of cancer cells from one site to another …

The physical sciences and engineering have introduced novel perspectives into the study of
cancer through model systems, tools, and metrics that enable integration of basic science …

A cell undergoes many genetic and epigenetic changes as it transitions to malignancy.
Malignant transformation is also accompanied by a progressive loss of tissue homeostasis …