The glymphatic system's role in traumatic brain injury-related neurodegeneration
ME Peters, CG Lyketsos - Molecular psychiatry, 2023 - nature.com
In at least some individuals who suffer a traumatic brain injury (TBI), there exists a risk of
future neurodegenerative illness. This review focuses on the association between the brain …
future neurodegenerative illness. This review focuses on the association between the brain …
The bidirectional link between sleep disturbances and traumatic brain injury symptoms: A role for glymphatic dysfunction?
Mild traumatic brain injury (mTBI), often referred to as concussion, is a major cause of
morbidity and mortality worldwide. Sleep disturbances are common after mTBI. Moreover …
morbidity and mortality worldwide. Sleep disturbances are common after mTBI. Moreover …
[HTML][HTML] The glymphatic system: a novel therapeutic target for stroke treatment
T Lv, B Zhao, Q Hu, X Zhang - Frontiers in Aging Neuroscience, 2021 - frontiersin.org
The glymphatic system (GS) is a novel defined brain-wide perivascular transit network
between cerebrospinal fluid (CSF) and interstitial solutes that facilitates the clearance of …
between cerebrospinal fluid (CSF) and interstitial solutes that facilitates the clearance of …
Glymphatic system disruption as a mediator of brain trauma and chronic traumatic encephalopathy
Traumatic brain injury (TBI) is an increasingly important issue among veterans, athletes and
the general public. Difficulties with sleep onset and maintenance are among the most …
the general public. Difficulties with sleep onset and maintenance are among the most …
[HTML][HTML] The glymphatic system: a new perspective on brain diseases
Z Ding, X Fan, Y Zhang, M Yao, G Wang… - Frontiers in Aging …, 2023 - frontiersin.org
The glymphatic system is a brain-wide perivascular pathway driven by aquaporin-4 on the
endfeet of astrocytes, which can deliver nutrients and active substances to the brain …
endfeet of astrocytes, which can deliver nutrients and active substances to the brain …
Glymphatic clearance estimated using diffusion tensor imaging along perivascular spaces is reduced after traumatic brain injury and correlates with plasma …
The glymphatic system is a perivascular fluid clearance system, most active during sleep,
considered important for clearing the brain of waste products and toxins. Glymphatic failure …
considered important for clearing the brain of waste products and toxins. Glymphatic failure …
[HTML][HTML] Perivascular unit: This must be the place. The anatomical crossroad between the immune, vascular and nervous system
F Troili, V Cipollini, M Moci, E Morena… - Frontiers in …, 2020 - frontiersin.org
Most neurological disorders seemingly have heterogenous pathogenesis, with overlapping
contribution of neuronal, immune and vascular mechanisms of brain injury. The perivascular …
contribution of neuronal, immune and vascular mechanisms of brain injury. The perivascular …
Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury
JJ Iliff, MJ Chen, BA Plog, DM Zeppenfeld… - Journal of …, 2014 - Soc Neuroscience
Traumatic brain injury (TBI) is an established risk factor for the early development of
dementia, including Alzheimer's disease, and the post-traumatic brain frequently exhibits …
dementia, including Alzheimer's disease, and the post-traumatic brain frequently exhibits …
[HTML][HTML] Vascular risk factors and astrocytic marker for the glymphatic system activity
Objectives Glymphatic system maintains brain fluid circulation via active transportation of
astrocytic aquaporin-4 in perivascular space. The diffusion tensor imaging analysis along …
astrocytic aquaporin-4 in perivascular space. The diffusion tensor imaging analysis along …
[HTML][HTML] Glymphatic system a window on TBI pathophysiology: a systematic review
M Ferrara, G Bertozzi, G Volonnino, N Di Fazio… - International Journal of …, 2022 - mdpi.com
Background: In recent years, the attention of the scientific world has focused on a clearance
system of brain waste metabolites, called the glymphatic system, based on its similarity to …
system of brain waste metabolites, called the glymphatic system, based on its similarity to …