The glymphatic system's role in traumatic brain injury-related neurodegeneration

ME Peters, CG Lyketsos - Molecular psychiatry, 2023 - nature.com
In at least some individuals who suffer a traumatic brain injury (TBI), there exists a risk of
future neurodegenerative illness. This review focuses on the association between the brain …

The bidirectional link between sleep disturbances and traumatic brain injury symptoms: A role for glymphatic dysfunction?

JA Piantino, JJ Iliff, MM Lim - Biological psychiatry, 2022 - Elsevier
Mild traumatic brain injury (mTBI), often referred to as concussion, is a major cause of
morbidity and mortality worldwide. Sleep disturbances are common after mTBI. Moreover …

[HTML][HTML] The glymphatic system: a novel therapeutic target for stroke treatment

T Lv, B Zhao, Q Hu, X Zhang - Frontiers in Aging Neuroscience, 2021 - frontiersin.org
The glymphatic system (GS) is a novel defined brain-wide perivascular transit network
between cerebrospinal fluid (CSF) and interstitial solutes that facilitates the clearance of …

Glymphatic system disruption as a mediator of brain trauma and chronic traumatic encephalopathy

MJ Sullan, BM Asken, MS Jaffee, ST DeKosky… - Neuroscience & …, 2018 - Elsevier
Traumatic brain injury (TBI) is an increasingly important issue among veterans, athletes and
the general public. Difficulties with sleep onset and maintenance are among the most …

[HTML][HTML] The glymphatic system: a new perspective on brain diseases

Z Ding, X Fan, Y Zhang, M Yao, G Wang… - Frontiers in Aging …, 2023 - frontiersin.org
The glymphatic system is a brain-wide perivascular pathway driven by aquaporin-4 on the
endfeet of astrocytes, which can deliver nutrients and active substances to the brain …

Glymphatic clearance estimated using diffusion tensor imaging along perivascular spaces is reduced after traumatic brain injury and correlates with plasma …

T Butler, L Zhou, I Ozsahin, XH Wang… - Brain …, 2023 - academic.oup.com
The glymphatic system is a perivascular fluid clearance system, most active during sleep,
considered important for clearing the brain of waste products and toxins. Glymphatic failure …

[HTML][HTML] Perivascular unit: This must be the place. The anatomical crossroad between the immune, vascular and nervous system

F Troili, V Cipollini, M Moci, E Morena… - Frontiers in …, 2020 - frontiersin.org
Most neurological disorders seemingly have heterogenous pathogenesis, with overlapping
contribution of neuronal, immune and vascular mechanisms of brain injury. The perivascular …

Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury

JJ Iliff, MJ Chen, BA Plog, DM Zeppenfeld… - Journal of …, 2014 - Soc Neuroscience
Traumatic brain injury (TBI) is an established risk factor for the early development of
dementia, including Alzheimer's disease, and the post-traumatic brain frequently exhibits …

[HTML][HTML] Vascular risk factors and astrocytic marker for the glymphatic system activity

YC Wei, CCH Hsu, WY Huang, C Lin, CK Chen… - La radiologia …, 2023 - Springer
Objectives Glymphatic system maintains brain fluid circulation via active transportation of
astrocytic aquaporin-4 in perivascular space. The diffusion tensor imaging analysis along …

[HTML][HTML] Glymphatic system a window on TBI pathophysiology: a systematic review

M Ferrara, G Bertozzi, G Volonnino, N Di Fazio… - International Journal of …, 2022 - mdpi.com
Background: In recent years, the attention of the scientific world has focused on a clearance
system of brain waste metabolites, called the glymphatic system, based on its similarity to …