Several members of the SLC26A family of anion transporters associate with CFTR, forming
complexes in which CFTR and SLC26A functions are reciprocally regulated. These …

Mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator
(CFTR) disrupt epithelial secretion and cause cystic fibrosis (CF). Available CFTR …

Aberrant anion secretion across the bronchial epithelium is associated with airway disease,
most notably in cystic fibrosis. Although the cystic fibrosis transmembrane conductance …

Human bronchial epithelial (HBE) cells exhibit constitutive anion secretion that is absent in
cells from cystic fibrosis (CF) patients. The identity of this conductance is unknown, but …

SLC26 proteins function as anion exchangers and Cl− channels. SLC26A9 has been
proposed to be a constitutively active and CFTR‐regulated anion conductance in human …

We investigated the possible functional‐and physical protein‐interactions between two
airway Cl− channels, SLC26A9 and CFTR. Bronchial CFBE41o‐cell lines expressing …

SLC26A9 is an epithelial anion transporter with a poorly defined function in airways. It is
assumed to contribute to airway chloride secretion and airway surface hydration. However …

Diffuse bronchiectasis is a common problem in respiratory clinics. We hypothesized that
mutations in the solute carrier 26A9 (SLC 26 A 9) gene, encoding for a chloride (Cl−) …

Cystic fibrosis is realizing the promise of personalized medicine. Recent advances in drug
development that target the causal CFTR directly result in lung function improvement, but …

Most epithelia that express CFTR secrete fluid rich in HCO3− and poor in Cl− that is
generated by a CFTR‐dependent Cl− absorption and HCO3− secretion process that when …