Structural Insights into the cl-Par-4 Protein: Ionic Requirements, Conformational Transitions, and Interaction With Cisplatin
KK Raut - 2023 - digitalcommons.odu.edu
Cancer continues to be the leading global cause of death, with challenges in early
diagnosis, drug resistance, non-specific drug targeting, and cancer recurrence and …
diagnosis, drug resistance, non-specific drug targeting, and cancer recurrence and …
Evidence of direct interaction between cisplatin and the caspase‐cleaved prostate apoptosis response‐4 tumor suppressor
Abstract Prostate apoptosis response‐4 (Par‐4) tumor suppressor protein has gained
attention as a potential therapeutic target owing to its unique ability to selectively induce …
attention as a potential therapeutic target owing to its unique ability to selectively induce …
Structural Analysis of the cl-Par-4 Tumor Suppressor as a Function of Ionic Environment
Prostate apoptosis response-4 (Par-4) is a proapoptotic tumor suppressor protein that has
been linked to a large number of cancers. This 38 kilodalton (kDa) protein has been shown …
been linked to a large number of cancers. This 38 kilodalton (kDa) protein has been shown …
pH-induced folding of the caspase-cleaved Par-4 tumor suppressor: evidence of structure outside of the coiled coil domain
AM Clark, K Ponniah, MS Warden, EM Raitt, AC Yawn… - Biomolecules, 2018 - mdpi.com
Prostate apoptosis response-4 (Par-4) is a 38 kDa largely intrinsically disordered tumor
suppressor protein that functions in cancer cell apoptosis. Par-4 down-regulation is often …
suppressor protein that functions in cancer cell apoptosis. Par-4 down-regulation is often …
Tetramer formation by the caspase‐activated fragment of the Par‐4 tumor suppressor
AM Clark, K Ponniah, MS Warden, EM Raitt… - The FEBS …, 2019 - Wiley Online Library
The prostate apoptosis response‐4 (Par‐4) tumor suppressor can selectively kill cancer
cells via apoptosis while leaving healthy cells unharmed. Full length Par‐4 has been shown …
cells via apoptosis while leaving healthy cells unharmed. Full length Par‐4 has been shown …
[PDF][PDF] Structural Analysis of the cl-Par-4 Tumor Suppressor as a Function of Ionic Environment. Biomolecules 2021, 11, 386
Prostate apoptosis response-4 (Par-4) is a proapoptotic tumor suppressor protein that has
been linked to a large number of cancers. This 38 kilodalton (kDa) protein has been shown …
been linked to a large number of cancers. This 38 kilodalton (kDa) protein has been shown …
Biophysical Characterization of the Par-4 Tumor Suppressor: Evidence of Structure Outside the Coiled Coil Domain and Interactions with Platinum Chemotherapeutics
AM Clark - 2021 - search.proquest.com
Abstract Prostate apoptosis response-4 (Par-4) is an apoptosis-inducing tumor suppressor
protein. Full-length Par-4 has previously been shown to be a predominantly intrinsically …
protein. Full-length Par-4 has previously been shown to be a predominantly intrinsically …
Regulation of cancer cell survival by Par‐4
P Ranganathan, VM Rangnekar - … of the New York Academy of …, 2005 - Wiley Online Library
Prostate apoptosis response‐4 (Par‐4) is a unique pro‐apoptotic protein that selectively
induces apoptosis in cancer cells. Moreover, Par‐4 sensitizes cells to the action of diverse …
induces apoptosis in cancer cells. Moreover, Par‐4 sensitizes cells to the action of diverse …
Prostate apoptosis response 4 (Par-4), a novel substrate of caspase-3 during apoptosis activation
Abstract Prostate apoptosis response 4 (Par-4) is a ubiquitously expressed proapoptotic
tumor suppressor protein. Here, we show for the first time, that Par-4 is a novel substrate of …
tumor suppressor protein. Here, we show for the first time, that Par-4 is a novel substrate of …
Enhancing the Conformational Stability of the cl-Par-4 Tumor Suppressor via Site-Directed Mutagenesis
Intrinsically disordered proteins play important roles in cell signaling, and dysregulation of
these proteins is associated with several diseases. Prostate apoptosis response-4 (Par-4) …
these proteins is associated with several diseases. Prostate apoptosis response-4 (Par-4) …
相关搜索
- interaction with cisplatin structural insights
- ionic requirements structural insights
- conformational transitions structural insights
- ionic requirements interaction with cisplatin
- conformational transitions interaction with cisplatin
- conformational transitions ionic requirements
- structural analysis ionic environment