Structural Insights into the cl-Par-4 Protein: Ionic Requirements, Conformational Transitions, and Interaction With Cisplatin

KK Raut - 2023 - digitalcommons.odu.edu
Cancer continues to be the leading global cause of death, with challenges in early
diagnosis, drug resistance, non-specific drug targeting, and cancer recurrence and …

Evidence of direct interaction between cisplatin and the caspase‐cleaved prostate apoptosis response‐4 tumor suppressor

KK Raut, S Pandey, G Kharel, SM Pascal - Protein Science, 2024 - Wiley Online Library
Abstract Prostate apoptosis response‐4 (Par‐4) tumor suppressor protein has gained
attention as a potential therapeutic target owing to its unique ability to selectively induce …

Structural Analysis of the cl-Par-4 Tumor Suppressor as a Function of Ionic Environment

KK Raut, K Ponniah, SM Pascal - Biomolecules, 2021 - mdpi.com
Prostate apoptosis response-4 (Par-4) is a proapoptotic tumor suppressor protein that has
been linked to a large number of cancers. This 38 kilodalton (kDa) protein has been shown …

pH-induced folding of the caspase-cleaved Par-4 tumor suppressor: evidence of structure outside of the coiled coil domain

AM Clark, K Ponniah, MS Warden, EM Raitt, AC Yawn… - Biomolecules, 2018 - mdpi.com
Prostate apoptosis response-4 (Par-4) is a 38 kDa largely intrinsically disordered tumor
suppressor protein that functions in cancer cell apoptosis. Par-4 down-regulation is often …

Tetramer formation by the caspase‐activated fragment of the Par‐4 tumor suppressor

AM Clark, K Ponniah, MS Warden, EM Raitt… - The FEBS …, 2019 - Wiley Online Library
The prostate apoptosis response‐4 (Par‐4) tumor suppressor can selectively kill cancer
cells via apoptosis while leaving healthy cells unharmed. Full length Par‐4 has been shown …

[PDF][PDF] Structural Analysis of the cl-Par-4 Tumor Suppressor as a Function of Ionic Environment. Biomolecules 2021, 11, 386

KK Raut, K Ponniah, SM Pascal - 2021 - brookhaveninstruments.com.cn
Prostate apoptosis response-4 (Par-4) is a proapoptotic tumor suppressor protein that has
been linked to a large number of cancers. This 38 kilodalton (kDa) protein has been shown …

Biophysical Characterization of the Par-4 Tumor Suppressor: Evidence of Structure Outside the Coiled Coil Domain and Interactions with Platinum Chemotherapeutics

AM Clark - 2021 - search.proquest.com
Abstract Prostate apoptosis response-4 (Par-4) is an apoptosis-inducing tumor suppressor
protein. Full-length Par-4 has previously been shown to be a predominantly intrinsically …

Regulation of cancer cell survival by Par‐4

P Ranganathan, VM Rangnekar - … of the New York Academy of …, 2005 - Wiley Online Library
Prostate apoptosis response‐4 (Par‐4) is a unique pro‐apoptotic protein that selectively
induces apoptosis in cancer cells. Moreover, Par‐4 sensitizes cells to the action of diverse …

Prostate apoptosis response 4 (Par-4), a novel substrate of caspase-3 during apoptosis activation

P Chaudhry, M Singh, S Parent… - Molecular and cellular …, 2012 - Am Soc Microbiol
Abstract Prostate apoptosis response 4 (Par-4) is a ubiquitously expressed proapoptotic
tumor suppressor protein. Here, we show for the first time, that Par-4 is a novel substrate of …

Enhancing the Conformational Stability of the cl-Par-4 Tumor Suppressor via Site-Directed Mutagenesis

S Pandey, KK Raut, AM Clark, A Baudin, L Djemri… - Biomolecules, 2023 - mdpi.com
Intrinsically disordered proteins play important roles in cell signaling, and dysregulation of
these proteins is associated with several diseases. Prostate apoptosis response-4 (Par-4) …