Zoonoses such as ZIKV and SARS-CoV-2 pose a severe risk to global health. There is
urgent need for broad antiviral strategies based on host-targets filling gaps between …

Oncoprotein PIM1 kinase participates in many important biological processes, such as cell
proliferation, apoptosis, carcinogenesis and tumorigenesis, by phosphorylating cellular …

The type I interferon (IFN) response is the major host arsenal against invading viruses. IRGM
is a negative regulator of IFN responses under basal conditions. However, the role of human …

AMP-activated protein kinase (AMPK) plays a central role in regulating cell energy balance.
When activated, AMPK supresses energy-consuming pathways such as lipid and protein …

Chikungunya virus (CHIKV) epidemics around the world have created public health concern
with the unavailability of effective drugs and vaccines. This emphasizes the need for …

Host kinases play essential roles in the host cell cycle, innate immune signaling, the stress
response to viral infection, and inflammation. Previous work has demonstrated that …

Background Recognition of viral invasion by innate antiviral immune system triggers
activation of the type I interferon (IFN-I) and proinflammatory signaling pathways …

Background The emerging threat to global health associated with the Zika virus (ZIKV)
epidemics and its link to severe complications highlights a growing need to better …

Flaviviruses continue to emerge as global health threats. There are currently no Food and
Drug Administration (FDA) approved antiviral treatments for flaviviral infections. Therefore …

Mayaro virus (MAYV) manipulates cell machinery to successfully replicate. Thus, identifying
host proteins implicated in MAYV replication represents an opportunity to discover potential …