Objective Chondrocyte hypertrophic differentiation, a key process in endochondral
ossification, is also a feature of osteoarthritis leading to cartilage destruction. Here we …

Objective Osteoarthritis (OA) is a common and highly debilitating degenerative disease
whose complex pathogenesis and the multiplicity of the molecular processes involved …

Runx2 is a known master transcription factor for osteoblast differentiation, as well as an
essential regulator for chondrocyte maturation. Recently, more and more data has shown …

Osteoarthritis (OA) is the most common joint disease affecting close to 27 million Americans.
The pathological change of OA joint is characterized by cartilage degradation and …

Background The cartilage stem/progenitor cells (CSPC) play a critical role in maintaining
cartilage homeostasis. However, the effects of phenotypic fluctuations of CSPC on cartilage …

Osteoarthritis (OA), one of the most common skeletal disorders characterized by cartilage
degradation and osteophyte formation in joints, is induced by accumulated mechanical …

Hypertrophic differentiation of chondrocytes is a main barrier in application of mesenchymal
stem cells (MSCs) for cartilage repair. In addition, hypertrophy occurs occasionally in …

As articular cartilage has a limited ability to self‐repair, successful cartilage regeneration
requires clinical‐grade chondrocytes with innate characteristics. However, cartilage …

Summary Objective Exostosin-1 (EXT1) and EXT2 are the major genetic etiologies of
multiple hereditary exostoses and are essential for heparan sulfate (HS) biosynthesis …

Osteoarthritis (OA) is the most common chronic joint disease and leads to the degradation of
the extracellular matrix by an imbalance between anabolic and catabolic processes. TGF-β3 …