[HTML][HTML] Phosphoinositide-3-kinase regulatory subunit 4 participates in the occurrence and development of amyotrophic lateral sclerosis by regulating autophagy
Y Liu, CH Wei, C Li, WZ Chen, Y Zhu… - Neural Regeneration …, 2022 - journals.lww.com
The development of amyotrophic lateral sclerosis (ALS) may be related to the abnormal
alterations of multiple proteins. Our previous study revealed that the expression of …
alterations of multiple proteins. Our previous study revealed that the expression of …
[HTML][HTML] Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic …
Background Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease
that affects spinal cord and cortical motor neurons. An increasing amount of evidence …
that affects spinal cord and cortical motor neurons. An increasing amount of evidence …
IRAK-M plays a role in the pathology of amyotrophic lateral sclerosis through suppressing the activation of microglia
X Zhong, C Li, Y Li, Y Huang, J Liu, A Jiang… - Molecular …, 2024 - Springer
Microglial activation plays a crucial role in the disease progression in amyotrophic lateral
sclerosis (ALS). Interleukin receptor-associated kinases-M (IRAK-M) is an important …
sclerosis (ALS). Interleukin receptor-associated kinases-M (IRAK-M) is an important …
The Temporal and Spatial Changes of Autophagy and PI3K Isoforms in Different Neural Cells After Hypoxia/Reoxygenation Injury
D Zhang, X Chen, B Liu, Y Yuan, W Cui, D Zhu… - Molecular …, 2023 - Springer
There are limited therapeutic options for patient with traumatic spinal cord injury (SCI).
Phosphoinositide 3-kinase family (PI3Ks) are the key molecules for regulating cell …
Phosphoinositide 3-kinase family (PI3Ks) are the key molecules for regulating cell …
Genetic ablation of IP3 receptor 2 increases cytokines and decreases survival of SOD1G93A mice
KA Staats, S Humblet-Baron… - Human molecular …, 2016 - academic.oup.com
Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease
characterized by the selective death of motor neurons. Disease pathophysiology is complex …
characterized by the selective death of motor neurons. Disease pathophysiology is complex …
BL-918, a small-molecule activator of ULK1, induces cytoprotective autophagy for amyotrophic lateral sclerosis therapy
W Liu, S Zhu, Y Guo, L Tu, Y Zhen, R Zhao… - Acta Pharmacologica …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is one of the most common fatal neurodegenerative
diseases in adults. ALS pathogenesis is associated with toxic SOD1 aggregates generated …
diseases in adults. ALS pathogenesis is associated with toxic SOD1 aggregates generated …
Switching the Proteolytic System from the Ubiquitin–Proteasome System to Autophagy in the Spinal Cord of an Amyotrophic Lateral Sclerosis Mouse Model
K Tadokoro, T Yamashita, J Shang, Y Ohta, E Nomura… - Neuroscience, 2021 - Elsevier
The degradation of damaged proteins takes place via two major proteolytic pathways: the
ubiquitin–proteasome system (UPS) and autophagy. However, since it is unclear how these …
ubiquitin–proteasome system (UPS) and autophagy. However, since it is unclear how these …
[HTML][HTML] Mitigating Motor Neuronal Loss in C. elegans Model of ALS8
W Zhang, A Colavita, JK Ngsee - Scientific reports, 2017 - nature.com
ALS8 is a late-onset familial autosomal dominant form of Amyotrophic Lateral Sclerosis
(ALS) caused by a point mutation (P56S) in the VAPB gene (VAMP associated protein …
(ALS) caused by a point mutation (P56S) in the VAPB gene (VAMP associated protein …
[HTML][HTML] Axonal degeneration: RIPK1 multitasking in ALS
K Politi, S Przedborski - Current Biology, 2016 - cell.com
A recent study reports that microglia and oligodendrocytes promote motor neuron
degeneration by inducing inflammation and necroptosis in a manner dependent on receptor …
degeneration by inducing inflammation and necroptosis in a manner dependent on receptor …
[HTML][HTML] Insulin‑like growth factor 1 promotes neurological functional recovery after spinal cord injury through inhibition of autophagy via the PI3K/Akt/mTOR signaling …
D Zhang, Y Yuan, J Zhu, D Zhu… - Experimental and …, 2021 - spandidos-publications.com
Spinal cord injury (SCI) is a serious trauma; however, the mechanisms underlying the role of
insulin‑like growth factor 1 (IGF‑1) in autophagy following SCI remain to be elucidated. The …
insulin‑like growth factor 1 (IGF‑1) in autophagy following SCI remain to be elucidated. The …