It is estimated that nearly a third of people who abuse drugs started with prescription opioid
medicines. Approximately, 11.5 million Americans used prescription drugs recreationally in …

Abstract Purpose of Review This study and literature review were carried out to investigate
whether oxycodone is the most addictive prescription opioid. Recent Findings This was a …

Oxycodone, a semisynthetic derivative of naturally occurring thebaine, an opioid alkaloid,
has been available for more than 100 years. Although thebaine cannot be used …

Opioid drugs are potent modulators of many physiological and psychological processes.
When given acutely, they can elicit the signature responses of euphoria and analgesia that …

Use of prescription opioids, particularly oxycodone, is an initiating factor driving the current
opioid epidemic. There are several challenges with modelling oxycodone abuse. First …

The widespread abuse of prescription opioids and a dramatic increase in the availability of
illicit opioids have created what is commonly referred to as the opioid epidemic. The …

The US opioid crisis came in three waves—prescription opioids, heroin, and illicitly
manufactured fentanyls—Centers for Disease Control and Prevention Centers for Disease …

Opioids were the most common drug class resulting in overdose deaths in the United States
in 2019. Widespread clinical use of prescription opioids for moderate to severe pain …

Importance More than 42 000 Americans died of opioid overdoses in 2016, and the fatalities
continue to increase. This review analyzes the factors that triggered the opioid crisis and its …

Introduction In the past decades, the opioid crisis has heavily impacted parts of the US
society and has been followed by an increase in the use of opioids worldwide. It is of …