Aims Caffeine is a methylxanthine with multiple actions in vascular smooth muscle cells
(VSMCs), including the increase in the intracellular Ca 2+(i Ca 2+) concentration by the …

The sarcoplasmic reticulum (SR)/plasma membrane (PM) junction plays an important role in
the control of the excitation‐contraction coupling of the vascular smooth muscle cells …

The present experiments were carried out to elucidate whether pharmacological nature of
caffeine (1 mM)-induced endothelium-dependent contraction (EDC) is different from that of …

Objective—In resistance arteries, there is an emerging view that smooth muscle CaV3. 2
channels restrain arterial constriction through a feedback response involving the large …

Background There is growing evidence suggesting involvement of L-type voltage-gated Ca
2+ channels (VGCCs) in purinergic signaling mechanisms. However, detailed interplay …

The purpose of this study was to investigate the effect of atropine on peripheral vasodilation
and the mechanisms involved. The isometric tension of rat mesenteric artery rings was …

The fluorescent dye fura-2 was used to study the effects of caffeine on cytosolic free Ca 2+
level ([Ca 2+] i) in freshly isolated single cells from the rat tail artery. Caffeine caused a …

Key points In arterial smooth muscle, Ca2+ sparks are elementary Ca2+‐release events
generated by ryanodine receptors (RyRs) to cause vasodilatation by opening maxi Ca2+ …

Effects of tetrandrine (TET), a bisbenzylisoquinoline alkaloid, on the contractile responses of
perfused rat mesenteric arteries to phenylephrine (PE) and caffeine were investigated. TET …

The aim of this work was to determine whether Capsaicin may exert a vascular regulation
through the activation of CB1 and/or CB2 receptors causing vasorelaxation in the rat aorta …