Hypertension is a heritable and major contributor to the global burden of disease. The sum
of rare and common genetic variants robustly identified so far explain only 1%–2% of the …

A recent genome-wide association study identified a locus on chromosome 16 in the
promoter region of the uromodulin (UMOD) gene that is associated with hypertension. Here …

Uromodulin, the major protein secreted in normal urine, is exclusively produced in the thick
ascending limb (TAL) cells of the kidney. The exact role uromodulin (UMOD) plays in renal …

The genetic architecture of blood pressure (BP) now includes more than 30 genes, with rare
mutations resulting in inherited forms of hypertension or hypotension, and 1477 common …

Uromodulin is expressed exclusively in the thick ascending limb and is the most abundant
protein excreted in normal urine. Variants in UMOD, which encodes uromodulin, are …

Hypertension and chronic kidney disease (CKD) are complex traits representing major
global health problems 1, 2. Multiple genome-wide association studies have identified …

Common variants in the region of the UMOD gene, which encodes uromodulin (Tamm-
Horsfall protein), associate with chronic kidney disease (CKD) and estimated GFR (eGFR) …

The kidney-specific gene UMOD encodes for uromodulin, the most abundant protein
excreted in normal urine. Rare large-effect variants in UMOD cause autosomal dominant …

Chronic kidney disease (CKD) is a worldwide public health problem that is associated with
substantial morbidity and mortality. To search for sequence variants that associate with CKD …

The identification of genetic factors associated with kidney disease has the potential to
provide critical insights into disease mechanisms. Genome-wide association studies have …