Neuroimaging epicenters as potential sites of onset of the neuroanatomical pathology in schizophrenia

Y Jiang, L Palaniyappan, C Luo, X Chang, J Zhang… - Science …, 2024 - science.org
Schizophrenia lacks a clear definition at the neuroanatomical level, capturing the sites of
origin and progress of this disorder. Using a network-theory approach called epicenter …

Common abnormal connectivity in first-episode and chronic schizophrenia in pre-and post-central regions: Implications for neuromodulation targeting

W Zhao, V Voon, K Xue, C Xie, J Kang, CP Lin… - Progress in Neuro …, 2022 - Elsevier
Schizophrenia is a neurodevelopmental disorder manifesting differing impairments at early
onset and chronic disease stages. Brain imaging research suggests a core pathological …

Heterogeneous Brain Abnormalities in Schizophrenia Converge on a Common Network Associated With Symptom Remission

Y Wang, Y Yang, W Xu, X Yao, X Xie… - Schizophrenia …, 2024 - academic.oup.com
Abstract Background and Hypothesis There is a huge heterogeneity of magnetic resonance
imaging findings in schizophrenia studies. Here, we hypothesized that brain regions …

Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study

F Georgiadis, S Larivière, D Glahn, LE Hong… - Molecular …, 2024 - nature.com
Schizophrenia is a prototypical network disorder with widespread brain-morphological
alterations, yet it remains unclear whether these distributed alterations robustly reflect the …

Emerging evidence of connectomic abnormalities in schizophrenia

M Rubinov, DS Bassett - Journal of Neuroscience, 2011 - Soc Neuroscience
Schizophrenia is an etiologically and clinically heterogeneous psychiatric disorder,
characterized by psychotic symptoms, motivational disturbances, and cognitive …

Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder—a systematic review of the magnetic resonance neuroimaging literature

B Birur, NV Kraguljac, RC Shelton, AC Lahti - NPJ schizophrenia, 2017 - nature.com
Abstract Since Emil Kraepelin's conceptualization of endogenous psychoses as dementia
praecox and manic depression, the separation between primary psychotic disorders and …

Anatomical insights into disrupted small-world networks in schizophrenia

Q Wang, TP Su, Y Zhou, KH Chou, IY Chen, T Jiang… - Neuroimage, 2012 - Elsevier
Schizophrenia is characterized by lowered efficiency in distributed information processing,
as indicated by research that identified a disrupted small-world functional network. However …

Neuroimaging as a window into the pathophysiological mechanisms of schizophrenia

NV Kraguljac, AC Lahti - Frontiers in psychiatry, 2021 - frontiersin.org
Schizophrenia is a complex neuropsychiatric disorder with a diverse clinical phenotype that
has a substantial personal and public health burden. To advance the mechanistic …

Symptom-circuit mappings of the schizophrenia connectome

Y Wang, J Wang, W Su, H Hu, M Xia, T Zhang, L Xu… - Psychiatry …, 2023 - Elsevier
Objective This paper aims to model the anatomical circuits underlying schizophrenia
symptoms, and to explore patterns of abnormal connectivity among brain networks affected …

[HTML][HTML] Voxel-based, brain-wide association study of aberrant functional connectivity in schizophrenia implicates thalamocortical circuitry

W Cheng, L Palaniyappan, M Li, KM Kendrick… - npj …, 2015 - nature.com
Background: Wernicke's concept of 'sejunction'or aberrant associations among specialized
brain regions is one of the earliest hypotheses attempting to explain the myriad of symptoms …