Abstract The human Dubin‐Johnson syndrome (DJS) is a rare autosomal recessive liver
disorder characterized by chronic conjugated hyperbilirubinemia. Patients have impaired …

Abstract The human Dubin-Johnson syndrome is an autosomal recessive liver disease
characterized by a chronic conjugated hyperbilirubinemia. Patients have impaired …

Dubin-Johnson syndrome (DJS) is an autosomal recessive disease characterized by
conjugated hyperbilirubinemia. Previous studies of the defects in the human canalicular …

Members of the ATP-binding cassette (ABC) transporter superfamily are mutated to cause
diseases that include cystic fibrosis, hyperinsulinemia, adrenoleukodys-trophy, Stargardt …

Abstract The Dubin–Johnson syndrome is an inherited disorder characterized by conjugated
hyperbilirubinemia. The deficient hepatobiliary transport of anionic conjugates is caused by …

Several organic anions are excreted into the bile via a canalicular multispecific organic
anion transporter (cMOAT), which is hereditarily defective in mutant rats, such as the Eisai …

Abstract The Dubin‐Johnson syndrome is characterized by an inherited defect in the
secretion of amphiphilic anionic conjugates from hepatocytes into the bile. We have recently …

The human Dubin-Johnson syndrome and its animal model, the TR− rat, are characterized
by a chronic conjugated hyperbilirubinemia. TR− rats are defective in the canalicular …

TR-mutant Wistar rats secrete markedly fewer organic anions other than bile acids from the
liver into the bile than do control rats. Fluorescence-image analysis of isolated normal and …

Absence of a functional multidrug resistance protein 2 (MRP2; symbol ABCC2) from the
hepatocyte canalicular membrane is the molecular basis of Dubin-Johnson syndrome, an …