Thymine DNA glycosylase (TDG) is a multifunctional protein that plays important roles in
DNA repair, DNA demethylation, and transcriptional regulation. These diverse functions …

Simple Summary Thymine DNA Glycosylase (TDG) is a DNA repair protein that plays an
important role in gene regulation. Recent studies have shown that TDG interacts with …

Melanoma is an aggressive neoplasm with increasing incidence that is classified by the NCI
as a recalcitrant cancer, ie, a cancer with poor prognosis, lacking progress in diagnosis and …

Thymine DNA glycosylase (TDG) belongs to the superfamily of uracil DNA glycosylases
(UDG) and is the first enzyme in the base-excision repair pathway (BER) that removes …

Abstract Thymine DNA Glycosylase (TDG) is a base excision repair enzyme that acts as a
thymine and uracil DNA N-glycosylase on G: T and G: U mismatches, thus protecting CpG …

Thymine− DNA glycosylases (TDGs) initiate base excision repair by debasification of the
erroneous thymine or uracil nucleotide in G· T and G· U mispairs which arise at high …

Thymine DNA glycosylase (TDG) is a base excision repair (BER) enzyme, which is
implicated in correction of deamination‐induced DNA mismatches, the DNA demethylation …

Human thymine‐DNA glycosylase (TDG) is well known to excise thymine and uracil from G·
T and G· U mismatches, respectively, and was therefore proposed to play a central role in …

DNA methylation is a major epigenetic mechanism for gene silencing. Whereas
methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions …

Thymine DNA glycosylase (TDG) is an essential enzyme playing multiple roles in base
excision repair, transcription regulation, and DNA demethylation. TDG mediates the …