Low mitochondrial number and activity have been suggested as underlying factors in
obesity, type 2 diabetes, and metabolic syndrome. However, the stage at which …

White adipose tissue is one of the largest organs of the body. It plays a key role in whole‐
body energy status and metabolism; it not only stores excess energy but also secretes …

Aims/hypothesis Mitochondrial oxidative phosphorylation (OxPhos) is essential for energy
production and survival. However, the tissue-specific and systemic metabolic effects of …

The objective of this study was to further establish and confirm the relationship of adipose
mitochondrial biogenesis in diabetes/obesity and the effects of rosiglitazone (RSG), a …

Background Mitochondrial alterations have been observed in subjects with metabolic
disorders such as obesity and diabetes. Studies on animal models and cell cultures suggest …

Obesity and type 2 diabetes are associated with mitochondrial dysfunction in adipose tissue,
but the role for adipose tissue mitochondria in the development of these disorders is …

The tissue-specific role of mitochondrial respiratory capacity in the development of insulin
resistance and type 2 diabetes is unclear. We determined mitochondrial function in glycolytic …

Context: It has been suggested that mitochondrial dysfunction in adipocytes contributes to
obesity-related metabolic complications. However, obesity results in adipocyte hypertrophy …

The notion that mitochondria contribute to obesity-induced insulin resistance is highly
debated. Therefore, we determined whether obese (BMI 33 kg/m2), insulin-resistant women …

Mitochondrial function refers to a broad spectrum of features such as resting mitochondrial
activity,(sub) maximal oxidative phosphorylation capacity (OXPHOS), and mitochondrial …