Ascent to high altitude is associated with physiological responses that counter the stress of
hypobaric hypoxia by increasing oxygen delivery and by altering tissue oxygen utilisation …

At high altitude, hypobaric hypoxia is a significant stress for humans and other animals,
challenging oxygen homeostasis and therefore tissue metabolism. Genetic signals of …

The Himalayan Sherpas, a human population of Tibetan descent, are highly adapted to life
in the hypobaric hypoxia of high altitude. Mechanisms involving enhanced tissue oxygen …

Recent studies have identified genes involved in high-altitude adaptation in Tibetans.
Genetic variants/haplotypes within regions containing three of these genes (EPAS1, EGLN1 …

The Tibetan Plateau is one of the highest regions on Earth. Tibetan highlanders are adapted
to life and reproduction in a hypoxic environment and possess a suite of distinctive …

Some highland populations have genetic adaptations that enable their successful existence
in a hypoxic environment. Tibetans are protected against many of the harmful responses …

Humans have adapted to the chronic hypoxia of high altitude in several locations, and
recent genome-wide studies have indicated a genetic basis. In some populations, genetic …

New Findings What is the topic of this review? The topic of this review is how Tibetans have
adapted genetically to high altitude, particularly with reference to altitude‐induced changes …

Tibetan natives have lived on the Tibetan plateau (altitude∼ 4,000 m) for at least 25,000
years, and as such they are adapted to life and reproduction in a hypoxic environment …

High altitude, defined as elevations lying above 2500 m sea level, challenges human
survival and reproduction. This environment provides a natural experimental design wherein …