Maternal age has a significant effect on oocyte developmental competence. Overall,
evidence suggests that oocytes from both prepubertal females and reproductively aged …

The widespread use of a variety of assisted reproductive technologies has removed many of
the constraints that previously restricted mammalian reproduction to the period between …

Mitochondrial therapeutics such as NAD+-boosting used during the oocyte's growth phase
markedly improve oocyte quality in mice. Evaluating them in humans should focus on …

Follicular microenvironment is paramount in the acquisition of oocyte competence, which is
dependent on two interconnected and interdependent processes: nuclear and cytoplasmic …

To investigate the effects of maternal age on the quality of oocytes, we used single-cell RNA
sequencing to detect global gene transcriptome and identify key genes affected by …

In recent years, postponement of marriage and childbearing in women of reproductive age
has led to an increase in the incidence of age-related infertility. The reproductive aging …

It has become a current social trend for women to delay childbearing. However, the quality of
oocytes from older females is compromised and the pregnancy rate of older women is lower …

The age‐associated decline in female fertility is largely ascribable to a decrease in oocyte
quality. This phenomenon is multifaceted and influenced by numerous interconnected …

In mammalian species an optimal fertilization window during which successful fertilization
occurs. In the majority of mammals estrus marks ovulation time and coincident with mating …

Reproductive capacity in women starts to decline beyond their mid-30s and pregnancies in
older women result in higher rates of miscarriage with aneuploidy. Age-related decline in …