Melatonin is synthesized in the pineal gland at night. Since melatonin is produced in the
mitochondria of all other cells in a non-circadian manner, the amount synthesized by the …

In cancer cells, glucose is primarily metabolized to pyruvate and then to lactate in the
cytosol. By allowing the conversion of pyruvate to acetyl-CoA in mitochondria, melatonin …

Melatonin has the ability to intervene in the initiation, progression and metastasis of some
experimental cancers. A large variety of potential mechanisms have been advanced to …

It was a surprising discovery when mitochondria, as the power houses of cells, were also
found to synthesize the potent mitochondrial targeted antioxidant, melatonin. The melatonin …

Glucose is an essential nutrient for every cell but its metabolic fate depends on cellular
phenotype. Normally, the product of cytosolic glycolysis, pyruvate, is transported into …

This review presents a hypothesis to explain the role of melatonin in regulating glucose
metabolism in cancer cells. Many cancer cells use cytosolic glycolysis (the Warburg effect) to …

For several years, oncostatic and antiproliferative properties, as well as thoses of cell death
induction through 5-methoxy-N-acetiltryptamine or melatonin treatment, have been known …

This commentary reviews the concept of the circadian melatonin rhythm playing an essential
role in reducing the development of diseases such as solid tumors which adopt cytosolic …

Several oncogenic pathways plus local microenvironmental conditions, such as hypoxia,
converge on the regulation of cancer cells metabolism. The major metabolic alteration …

Although there is one exception (red blood cells), the lack of energy (ATP) provided by
mitochondrial oxidative phosphorylation (OXPHOS) is not compatible with the long-term …