Abstract Interleukin 35 (IL-35) is a newly discovered inhibitory cytokine of the IL12 family.
More recently, IL-35 was found to be increased in the tumor microenvironment (TME) and …

Interleukin-35 (IL-35) is a heterodimeric cytokine composed of Epstein-Barr virus-induced
gene 3 (EBI3) and IL-12p35 that has recently been shown to play diverse and important …

IL-35 is the newest member of IL-12 family. A dimeric protein consisting of two separate
subunits has manifested suppressive actions on immune system, which is counterproductive …

Regulatory T (Treg) cells pose a major barrier to effective anti-tumor immunity. Although
Treg cell depletion enhances tumor rejection, the ensuing autoimmune sequelae limits its …

IL-35 is a member of the IL-12 family of cytokines that is comprised of an IL-12 p35 subunit
and an IL-12 p40-related protein subunit, EBV-induced gene 3 (EBI3). IL-35 functions …

IL-35 is a novel heterodimeric and inhibitory cytokine, composed of interleukin-12 subunit
alpha (P35) and Epstein-Barr virus-induced gene 3 (EBI3). IL-35 has been reported to be …

The role of the immune system in anti-tumor immunity cannot be overstated, as it holds the
potential to promote tumor eradication or prevent tumor cell escape. Cytokines are critical to …

IL-35 is an immunosuppressive cytokine and exerts regulatory effects on T cells, B cells,
macrophages and dendritic cells. Neutrophils are important innate immune cells that play …

Background Interleukin-35 (IL-35), a novel immune-suppressing cytokine, can promote
tumor angiogenesis and inhibits anti-tumor cytotoxic lymphocyte response. Here, we aimed …

Immunosuppressive functions conferred by regulatory cytokines are important for
maintaining homeostasis in immune responses. IL35 has recently emerged as a novel …