We need novel strategies to target the complexity of cancer and, particularly, of metastatic
disease. As an example of this complexity, certain tissues are particularly hospitable …

Simple Summary The extracellular matrix acts as scaffolding to support the structure and
function of the cells in our body. In cancer, this matrix is altered in a way that helps cancer …

Tumor progression and dissemination critically depend on support from the tumor
microenvironment, the ensemble of cellular and acellular components surrounding and …

The extracellular matrix (ECM) plays a crucial role in regulating organ homeostasis. It
provides mechanical and biochemical cues directing cellular behaviour and, therefore, has …

The main cause of cancer-related mortality, metastasis, is a complex, multi-step process.
The extracellular matrix (ECM) component of solid tumors has been implicated in metastatic …

The microenvironment plays a central role in cancer, and neoplastic cells actively shape it to
their needs by complex arrays of extracellular matrix (ECM) proteins, enzymes, cytokines …

The extracellular matrix (ECM) is a complex meshwork of cross-linked proteins providing
both biophysical and biochemical cues that are important regulators of cell proliferation …

Modification of the extracellular matrix (ECM) is a critical aspect of developing a metastasis-
supportive organ niche. Recent work investigating ECM changes that facilitate metastasis …

Accumulation of damage is generally considered the cause of aging. Interventions that delay
aging mobilize mechanisms that protect and repair cellular components. Consequently …

Matricellular proteins have been classified as a family of non-structural matrix proteins
capable of modulating a variety of biological processes within the extracellular matrix (ECM) …