[HTML][HTML] A systematic review and meta-analysis of murine models of uremic cardiomyopathy

J Soppert, J Frisch, J Wirth, C Hemmers, P Boor… - Kidney international, 2022 - Elsevier
Chronic kidney disease (CKD) triggers the risk of developing uremic cardiomyopathy as
characterized by cardiac hypertrophy, fibrosis and functional impairment. Traditionally …

Cardiomyopathy in chronic kidney disease: clinical features, biomarkers and the contribution of murine models in understanding pathophysiology

CVC Junho, J Frisch, J Soppert… - Clinical Kidney …, 2023 - academic.oup.com
The cardiorenal syndrome (CRS) is described as a multi‐organ disease encompassing
bidirectionally heart and kidney. In CRS type 4, chronic kidney disease (CKD) leads to …

Myocardial dysfunction occurs prior to changes in ventricular geometry in mice with chronic kidney disease (CKD)

PD Winterberg, R Jiang, JT Maxwell… - Physiological …, 2016 - Wiley Online Library
Uremic cardiomyopathy is responsible for high morbidity and mortality rates among patients
with chronic kidney disease (CKD), but the underlying mechanisms contributing to this …

Mapping cardiac remodeling in chronic kidney disease

N Kaesler, M Cheng, J Nagai, J O'Sullivan… - Science …, 2023 - science.org
Patients with advanced chronic kidney disease (CKD) mostly die from sudden cardiac death
and recurrent heart failure. The mechanisms of cardiac remodeling are largely unclear. To …

Is uremic cardiomyopathy a direct consequence of chronic kidney disease?

S Chinnappa, SS Hothi, LB Tan - Expert review of cardiovascular …, 2014 - Taylor & Francis
Heart failure is a major cause of morbidity and mortality in chronic kidney disease (CKD).
Rather than merely secondary to traditional vascular factors, CKD is also an independent …

[HTML][HTML] Pro-oxidative priming but maintained cardiac function in a broad spectrum of murine models of chronic kidney disease

J Wollenhaupt, J Frisch, E Harlacher, DWL Wong, H Jin… - Redox biology, 2022 - Elsevier
Aims Patients with chronic kidney disease (CKD) have an increased risk of cardiovascular
events and exhibit myocardial changes including left ventricular (LV) hypertrophy and …

Cardiac remodeling in chronic kidney disease

N Kaesler, A Babler, J Floege, R Kramann - Toxins, 2020 - mdpi.com
Cardiac remodeling occurs frequently in chronic kidney disease patients and affects quality
of life and survival. Current treatment options are highly inadequate. As kidney function …

[HTML][HTML] Uremic cardiac hypertrophy is reversed by rapamycin but not by lowering of blood pressure

AM Siedlecki, X Jin, AJ Muslin - Kidney international, 2009 - Elsevier
Chronic kidney disease is often complicated by uremic cardiomyopathy that consists of left
ventricular hypertrophy and interstitial fibrosis. It is thought that hypertension and volume …

Pathological cardiac remodeling occurs early in CKD mice from unilateral urinary obstruction, and is attenuated by Enalapril

O Ham, W Jin, L Lei, HH Huang, K Tsuji, M Huang… - Scientific reports, 2018 - nature.com
Cardiovascular disease constitutes the leading cause of mortality in patients with chronic
kidney disease (CKD) and end-stage renal disease. Despite increasing recognition of a …

Cardiac metabolic remodelling in chronic kidney disease

N Patel, MM Yaqoob, D Aksentijevic - Nature Reviews Nephrology, 2022 - nature.com
Chronic kidney disease (CKD) affects millions of people globally and, for most patients, the
risk of developing cardiovascular disease is higher than that of progression to kidney failure …