Abstract Quinoline and 1, 2, 3-triazoles are well-known nitrogen-based heterocycles
presenting diverse pharmacological properties, although their antileishmanial activity is still …

Leishmaniasis is a group of infectious diseases caused by protozoan parasites that belong
to the genus Leishmania. Currently, there is no human vaccine, and the available treatments …

A series of 1-aryl-4-(4, 5-dihydro-1H-imidazol-2-yl)-1H-pyrazoles (4a–g) and 5-amino-1-aryl-
4-(4, 5-dihydro-1H-imidazol-2-yl)-1H-pyrazoles (5a–g) were synthesized and evaluated in …

The current standard treatment for leishmaniasis has remained the same for over 100 years,
despite inducing several adverse effects and increasing cases of resistance. In this study we …

Sixteen 1, 4-diaryl-1, 2, 3-triazole compounds 4–19 derived from the tetrahydrofuran
neolignans veraguensin 1, grandisin 2, and machilin G 3 were tested against Leishmania …

A novel series of trans-2-aryloxy-1, 2, 3, 4,-tetrahydronaphthyl azoles and related cyclohexyl
azoles were synthesized and evaluated in vitro against Leishmania donovani. Compound 9 …

The high potential of quinoline containing natural products and their derivatives in medicinal
chemistry led us to discover novel series of 25 compounds for the development of new …

In this research, a series of substituted 5‐(5‐amino‐1‐aryl‐1H‐pyrazol‐4‐yl)‐1H‐tetrazoles
were synthesized and evaluated for in vitro antileishmanial activity. Among the derivatives …

In our efforts to identify novel chemical scaffolds for the development of antileishmanial
agents, a series of quinoline–metronidazole hybrid compounds was synthesized and tested …

A series of novel indazole–pyrone hybrids were synthesized by a one pot reaction between
N-alkyl-6 (5)-nitroindazoles and 2-pyrone (4-hydroxy-6-methyl-2H-pyran-2-one) using …