Immuno-oncology not only refers to the multifaceted relationship between our immune
system and a developing cancer but also includes therapeutic approaches that harness the …

Cancer cells are characterized by sustained proliferative signaling, insensitivity to growth
suppressors and resistance to apoptosis as well as by replicative immortality, the capacity to …

Mevalonate metabolism provides cancer and immune cells with diverse products to ensure
cell functionality. Similar metabolic reprogramming that raises mevalonate metabolism to …

The metabolic reprogramming that drives immunity engages the mevalonate pathway for
cholesterol biosynthesis and protein prenylation. The importance of tight regulation of this …

Whereas resting T cells, which have low metabolic requirements, use oxidative
phosphorylation (OXPHOS) to maximize their generation of ATP, activated T cells, similar to …

The mevalonate pathway for cholesterol biosynthesis and protein prenylation has been
implicated in various aspects of tumor development and progression. Certain classes of …

The mevalonate pathway is a highly conserved metabolic cascade and provides isoprenoid
building blocks for the biosynthesis of vital cellular products such as cholesterol or prenyl …

Motivated by the clinical observation that interruption of the mevalonate pathway stimulates
immune responses, we hypothesized that this pathway may function as a druggable target …

Mevalonate pathway is a highly conserved pathway that produces isoprenoids and
cholesterol, and it is often increased in cancer cells. Cholesterol, upstream metabolites …

Hyperactive mevalonate (MVA) metabolic activity is often observed in cancer cells, and
blockade of this pathway inhibits tumor cell lipid synthesis and cell growth and enhances …