Host defense peptides: front-line immunomodulators

SC Mansour, OM Pena, REW Hancock - Trends in immunology, 2014 - cell.com
Although first studied for their antimicrobial activity, host defense peptides (HDPs) are now
widely recognized for their multifunctional roles in both the innate and adaptive immune …

The immunology of host defence peptides: beyond antimicrobial activity

REW Hancock, EF Haney, EE Gill - Nature Reviews Immunology, 2016 - nature.com
Host defence peptides (HDPs) are short, cationic amphipathic peptides with diverse
sequences that are produced by various cells and tissues in all complex life forms. HDPs …

Host defense peptides and their antimicrobial-immunomodulatory duality

L Steinstraesser, U Kraneburg, F Jacobsen… - Immunobiology, 2011 - Elsevier
Host defence peptides (HDPs) are short cationic molecules produced by the immune
systems of most multicellular organisms and play a central role as effector molecules of …

[HTML][HTML] Multifunctional cationic host defence peptides and their clinical applications

ATY Yeung, SL Gellatly, REW Hancock - Cellular and Molecular Life …, 2011 - Springer
With the rapid rise in the emergence of bacterial strains resistant to multiple classes of
antimicrobial agents, there is an urgent need to develop novel antimicrobial therapies to …

[HTML][HTML] Strategies in translating the therapeutic potentials of host defense peptides

DSJ Ting, RW Beuerman, HS Dua… - Frontiers in …, 2020 - frontiersin.org
The golden era of antibiotics, heralded by the discovery of penicillin, has long been
challenged by the emergence of antimicrobial resistance (AMR). Host defense peptides …

Antimicrobial host defence peptides: immunomodulatory functions and translational prospects

AM van der Does, PS Hiemstra… - … Peptides: Basics for …, 2019 - Springer
Cationic host defence peptides (CHDPs), also known as antimicrobial peptides, exhibit a
wide range of activities contributing to immune responses and resolution of infections …

Antimicrobial host defence peptides: functions and clinical potential

N Mookherjee, MA Anderson, HP Haagsman… - Nature reviews Drug …, 2020 - nature.com
Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are naturally
occurring peptides that can combat infections through their direct microbicidal properties …

Cationic host defence peptides: multifaceted role in immune modulation and inflammation

KY Choi, LNY Chow, N Mookherjee - Journal of innate immunity, 2012 - karger.com
Host defence peptides (HDPs) are innate immune effector molecules found in diverse
species. HDPs exhibit a wide range of functions ranging from direct antimicrobial properties …

[HTML][HTML] Reassessing the host defense peptide landscape

EF Haney, SK Straus, REW Hancock - Frontiers in chemistry, 2019 - frontiersin.org
Current research has demonstrated that small cationic amphipathic peptides have strong
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …

Exploring the pharmacological potential of promiscuous host-defense peptides: from natural screenings to biotechnological applications

ON Silva, KCL Mulder, AEAD Barbosa… - Frontiers in …, 2011 - frontiersin.org
In the last few years, the number of bacteria with enhanced resistance to conventional
antibiotics has dramatically increased. Most of such bacteria belong to regular microbial …