Multi-omics characterization of pancreatic neuroendocrine neoplasms

CFK Yang - 2021 - summit.sfu.ca
Pancreatic neuroendocrine neoplasms (PNENs) are biologically and clinically
heterogeneous neoplasms in which pathogenic alterations are often indiscernible …

[HTML][HTML] Proteotranscriptomic classification and characterization of pancreatic neuroendocrine neoplasms

KC Yang, SE Kalloger, JJ Aird, MKC Lee, C Rushton… - Cell reports, 2021 - cell.com
Pancreatic neuroendocrine neoplasms (PNENs) are biologically and clinically
heterogeneous. Here, we use a multi-omics approach to uncover the molecular factors …

Molecular characterization of metastatic pancreatic neuroendocrine tumors (PNETs) using whole-genome and transcriptome sequencing

H Wong, KC Yang, Y Shen… - Molecular …, 2018 - molecularcasestudies.cshlp.org
Pancreatic neuroendocrine tumors (PNETs) are a genomically and clinically heterogeneous
group of pancreatic neoplasms often diagnosed with distant metastases. Recurrent somatic …

P-76 Genomic and transcriptomic characterization of pancreatic neuroendocrine tumors reveals novel therapeutic candidates

A Azmi, Z Mahdi, S Bannoura, M Al-Hallak… - Annals of …, 2023 - annalsofoncology.org
Background Pancreatic neuroendocrine tumor (pNET) incidence is on the rise and remains
an unmet clinical problem in urgent need of new actionable targets. Methods We performed …

[HTML][HTML] Pancreatic neuroendocrine tumors: molecular mechanisms and therapeutic targets

CK Maharjan, PH Ear, CG Tran, JR Howe… - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers
whose causation is only partly understood. An increasing number of studies have uncovered …

[HTML][HTML] Molecular signatures and their clinical utility in pancreatic neuroendocrine tumors

PD Chatani, SK Agarwal, SM Sadowski - Frontiers in Endocrinology, 2021 - frontiersin.org
Pancreatic neuroendocrine tumors (PNETs) are classified based on their histologic
differentiation and proliferative indices, which have been used extensively to determine …

Molecular profile of pancreatic neuroendocrine neoplasms (PanNENs): Opportunities for personalized therapies

J Arakelyan, D Zohrabyan, PA Philip - Cancer, 2021 - Wiley Online Library
Pancreatic neuroendocrine neoplasms (panNENs) are the second most common epithelial
tumors of the pancreas. Despite improvements in prognostic grading and staging systems, it …

[HTML][HTML] Molecular biology of pancreatic neuroendocrine tumors: From mechanism to translation

X Shen, X Wang, X Lu, Y Zhao, W Guan - Frontiers in Oncology, 2022 - frontiersin.org
Pancreatic neuroendocrine tumors (pNETs) are a group of heterogeneous tumors originated
from progenitor cells. As these tumors are predominantly non-functional, most of them …

[HTML][HTML] Multiplatform profiling of pancreatic neuroendocrine tumors: Correlative analyses of clinicopathologic factors and identification of co-occurring pathogenic …

J Gong, EM Blais, JR Bender, M Guan… - Oncotarget, 2019 - ncbi.nlm.nih.gov
Background Multi-omic profiling of pancreatic neuroendocrine tumors (PanNETs) was
performed to correlate genomic, proteomic, and molecular pathway alterations with …

[HTML][HTML] An insight on functioning pancreatic neuroendocrine neoplasms

M Bevere, A Gkountakos, FM Martelli, A Scarpa… - Biomedicines, 2023 - mdpi.com
Pancreatic neuroendocrine neoplasms (PanNENs) are rare neoplasms arising from islets of
the Langerhans in the pancreas. They can be divided into two groups, based on peptide …