[HTML][HTML] Pharmacological mechanism of natural drugs and their active ingredients in the treatment of arrhythmia via calcium channel regulation

X Zhang, Y Gao, Y Zhou, Z Liu, R Liu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Arrhythmia is characterized by abnormal heartbeat rhythms and frequencies caused by
heart pacing and conduction dysfunction. Arrhythmia is the leading cause of death in …

Natural products as the calcium channel blockers for the treatment of arrhythmia: Advance and prospect

L Xiao, XJ Chen, JK Feng, WN Li, S Yuan, Y Hu - Fitoterapia, 2023 - Elsevier
Arrhythmia is one of the commonly heart diseases with observed abnormal heart-beat
rhythm that caused by the obstacles of cardiac activity and conduction. The arrhythmic …

Mechanism-based targeting of cardiac arrhythmias by phytochemicals and medicinal herbs: A comprehensive review of preclinical and clinical evidence

D Soltani, B Azizi, R Rahimi, AH Talasaz… - Frontiers in …, 2022 - frontiersin.org
Cardiac arrhythmias, characterized by an irregular heartbeat, are associated with high
mortality and morbidity. Because of the narrow therapeutic window of antiarrhythmic drugs …

[HTML][HTML] A review on plants and herbal components with antiarrhythmic activities and their interaction with current cardiac drugs

A Beik, S Joukar, H Najafipour - Journal of Traditional and Complementary …, 2020 - Elsevier
This paper aimed to compile information on plants or their compounds which have
experimentally shown antiarrhythmic effect and to scrutinize the efficacy and potency of them …

The role of biologically active ingredients from natural drug treatments for arrhythmias in different mechanisms

J Li, D Hu, X Song, T Han, Y Gao… - BioMed Research …, 2017 - Wiley Online Library
Arrhythmia is a disease that is caused by abnormal electrical activity in the heart rate or
rhythm. It is the major cause of cardiovascular morbidity and mortality. Although several …

[HTML][HTML] Chinese herbal medicine for the treatment of cardiovascular diseases─ Targeting cardiac ion channels

Z Yan, L Zhong, W Zhu, SK Chung, P Hou - Pharmacological Research, 2023 - Elsevier
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality,
imposing an increasing global health burden. Cardiac ion channels (voltage-gated Na V, Ca …

Research Progress on Natural Products' Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels

J He, S Li, Y Ding, Y Tong, X Li - Cardiovascular Therapeutics, 2022 - Wiley Online Library
Antiarrhythmic drugs (AADs) have a therapeutic effect on atrial fibrillation (AF) by regulating
the function of ion channels. However, several adverse effects and high recurrence rates …

Natural products as a source of antiarrhythmic drugs

AO Bryzgalov, TG Tolstikova, EE Shults… - Mini reviews in …, 2018 - ingentaconnect.com
Throughout the development of medicine, the spotlight has been held by the search for new
drugs blocking different types of arrhythmia. In the past decade, much attention was given to …

The alkaloid matrine of the root of Sophora flavescens prevents arrhythmogenic effect of ouabain

Y Zhou, Y Wu, L Deng, L Chen, D Zhao, L Lv, X Chen… - Phytomedicine, 2014 - Elsevier
Matrine, a alkaloid of the root of Sophora flavescens, has multiple protective effects on the
cardiovascular system including cardiac arrhythmias. However, the molecular and ionic …

Ginsenoside Rb1 exerts antiarrhythmic effects by inhibiting INa and ICaL in rabbit ventricular myocytes

Z Liu, L Song, P Zhang, Z Cao, J Hao, Y Tian, A Luo… - Scientific Reports, 2019 - nature.com
Ginsenoside Rb1 exerts its pharmacological action by regulating sodium, potassium and
calcium ion channels in the membranes of nerve cells. These ion channels are also present …