This review article describes the pathways and mechanisms of endocytosis and post-
endocytic sorting of the EGF receptor (EGFR/ErbB1) and other members of the ErbB family …

Publisher Summary This chapter describes the trafficking of ErbB receptors and its effect on
signaling. Although members of the ErbB receptor family are found predominantly at the cell …

The epidermal growth factor receptor (EGFR; also known as ErbB1) is one of four related
receptor tyrosine kinases. These receptors (EGFR, ErbB2, ErbB3 and ErbB4) are frequently …

Exosomes are small membrane vesicles derived from intracellular multivescicular bodies
(MVBs) that can undergo constitutive and regulated secretion from cells. Exosomes can also …

In contrast to the epidermal growth factor (EGF) receptor, ErbB2 is known to remain at the
plasma membrane after ligand binding and dimerization. However, why ErbB2 is not …

By constructing stably transfected cells harboring the same amount of epidermal growth
factor (EGF) receptor (EGFR), but with increasing overexpression of ErbB2, we have …

Endocytosis and subsequent lysosomal degradation serve as a well characterized
mechanism to fine-tune and down-regulate EGFR signaling. However, other members of the …

Abstract ErbB receptors (EGFR (ErbB1), ErbB2, ErbB3, and ErbB4) are important regulators
of normal growth and differentiation, and they are involved in the pathogenesis of cancer …

Both homo‐and hetero‐dimers of ErbB receptor tyrosine kinases mediate signaling by a
large group of epidermal growth factor (EGF)‐like ligands. However, some ligands are more …

Four transmembrane tyrosine kinases constitute the ErbB receptor family: the epidermal
growth factor (EGF) receptor, ErbB-2, ErbB-3, and ErbB-4. We have measured the endocytic …