Research ethics and the challenge of whole-genome sequencing

AL McGuire, T Caulfield, MK Cho - Nature Reviews Genetics, 2008 - nature.com
The recent completion of the first two individual whole-genome sequences is a research
milestone. As personal genome research advances, investigators and international research …

[HTML][HTML] Research ethics recommendations for whole-genome research: consensus statement

T Caulfield, AL McGuire, M Cho, JA Buchanan… - PLoS …, 2008 - journals.plos.org
Research Ethics Recommendations for Whole-Genome Research: Consensus Statement |
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The $1000 genome: ethical and legal issues in whole genome sequencing of individuals

JA Robertson - American Journal of Bioethics, 2003 - Taylor & Francis
Progress in gene sequencing could make rapid whole genome sequencing of individuals
affordable to millions of persons and useful for many purposes in a future era of genomic …

Personal genome research: what should the participant be told?

AL McGuire, JR Lupski - Trends in Genetics, 2010 - cell.com
Should the results of whole genome sequencing research be disclosed to participants, in
particular when the results have uncertain or indeterminate phenotypic consequences? This …

Genomics really gets personal: how exome and whole genome sequencing challenge the ethical framework of human genetics research

HK Tabor, BE Berkman, SC Hull… - American Journal of …, 2011 - Wiley Online Library
Exome sequencing (ES) and whole genome sequencing (WGS) putatively identify all
adverse functional alleles of protein‐coding genes. Accordingly, while ES/WGS are …

Revealing the results of whole-genome sequencing and whole-exome sequencing in research and clinical investigations: some ethical issues

N Hallowell, A Hall, C Alberg, R Zimmern - Journal of Medical Ethics, 2015 - jme.bmj.com
The introduction of new sequencing technologies whole-genome sequencing (WGS) and
whole-exome sequencing (WES) that are much less finely targeted than previous genetic …

[HTML][HTML] The 'thousand-dollar genome': an ethical exploration

WJ Dondorp, GMWR De Wert - European Journal of Human Genetics, 2013 - nature.com
Sequencing an individual's complete genome is expected to be possible for a relatively low
sum 'one thousand dollars' within a few years. Sequencing refers to determining the order of …

Genomic inheritances: disclosing individual research results from whole-exome sequencing to deceased participants' relatives

B Chan, FM Facio, H Eidem, SC Hull… - The American Journal …, 2012 - Taylor & Francis
Whole-genome analysis and whole-exome analysis generate many more clinically
actionable findings than traditional targeted genetic analysis. These findings may be …

[HTML][HTML] Ethical implications of the use of whole genome methods in medical research

J Kaye, P Boddington, J De Vries, N Hawkins… - European Journal of …, 2010 - nature.com
The use of genome-wide association studies (GWAS) in medical research and the increased
ability to share data give a new twist to some of the perennial ethical issues associated with …

Prenatal whole genome sequencing: just because we can, should we?

G Donley, SC Hull, BE Berkman - Hastings Center Report, 2012 - Wiley Online Library
Whole genome sequencing is quickly becoming more affordable and accessible, with the
prospect of personal genome sequencing for under $1,000 now widely said to be in sight …