Decreased mitochondrial electron transport proteins and increased complement mediators in plasma neural-derived exosomes of early psychosis

EJ Goetzl, VH Srihari, S Guloksuz, M Ferrara… - Translational …, 2020 - nature.com
Potentially neurotoxic systems involved in traumatic and degenerative diseases of the brain
were assessed in acute psychosis. Astrocyte-derived exosomes (ADEs) and neuron-derived …

Neural cell‐derived plasma exosome protein abnormalities implicate mitochondrial impairment in first episodes of psychosis

EJ Goetzl, VH Srihari, S Guloksuz, M Ferrara… - The FASEB …, 2021 - Wiley Online Library
Neuroprotective and other functional proteins of mitochondria were quantified in extracts of
plasma neural‐derived exosomes from ten first‐episode psychosis (FP) patients and ten …

Plasma levels of neuron-and astrocyte-derived exosomal amyloid beta1-42, amyloid beta1-40, and phosphorylated tau levels in schizophrenia patients and non …

EE Lee, C Winston-Gray, JW Barlow… - Frontiers in …, 2021 - frontiersin.org
Introduction: Cognitive deficits in people with schizophrenia (PWS) are a major predictor of
disability and functioning, yet the underlying pathophysiology remains unclear. A possible …

Analysis of circulating exosomes reveals a peripheral signature of astrocytic pathology in schizophrenia

M Ranganathan, M Rahman, S Ganesh… - The World Journal of …, 2022 - Taylor & Francis
Objectives Extracellular vesicles, including exosomes, cross the blood brain barrier with
their contents intact and can be assayed peripherally. Circulating exosomes have been …

[HTML][HTML] Abnormal levels of mitochondrial Ca2+ channel proteins in plasma neuron-derived extracellular vesicles of early schizophrenia

EJ Goetzl, VH Srihari, M Mustapic… - … : official publication of …, 2022 - ncbi.nlm.nih.gov
Structural alterations or quantitative abnormalities of some mitochondrial ion channels and
exchangers are associated with altered neuronal functions and increased susceptibility to …

Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive …

D Guha, DR Lorenz, V Misra, S Chettimada… - Journal of …, 2019 - Springer
Abstract Background Extracellular vesicles (EVs) are nano-sized particles present in most
body fluids including cerebrospinal fluid (CSF). Little is known about CSF EV proteins in …

[HTML][HTML] Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer's disease …

CN Winston, EJ Goetzl, JB Schwartz, FM Elahi… - Alzheimer's & Dementia …, 2019 - Elsevier
Introduction Levels of complement proteins (CPs) in plasma astrocyte-derived exosomes
(ADEs) that are abnormal in Alzheimer's disease (AD) have not been assessed in mild …

Blood neuron-derived exosomes as biomarkers of cognitive impairment in HIV

B Sun, P Dalvi, L Abadjian, N Tang, L Pulliam - Aids, 2017 - journals.lww.com
Objective: To investigate proteins associated with neuronal damage in plasma neuron-
derived exosomes (NDE) of HIV-infected study participants as a liquid biomarker for …

RETRACTED: increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in the postmortem frontal cortex from …

JS Rao, HW Kim, GJ Harry, SI Rapoport, EA Reese - 2013 - Elsevier
Schizophrenia (SZ) is a progressive, neuropsychiatric disorder associated with cognitive
impairment. A number of brain alterations have been linked to cognitive impairment …

Serum neuronal exosomes predict and differentiate Parkinson's disease from atypical parkinsonism

C Jiang, F Hopfner, A Katsikoudi, R Hein… - Journal of Neurology …, 2020 - jnnp.bmj.com
Objective Parkinson's disease is characterised neuropathologically by α-synuclein
aggregation. Currently, there is no blood test to predict the underlying pathology or …