Publisher Summary This chapter reviews substantial anatomical data describing the
distribution of bradykinin (BK) receptors as well as that of the biochemical machinery for the …

The direction that research takes for a particular mediator is often dictated by the
circumstances of its discovery. In the case of the kinins, it was soon realised that bradykinin …

The nervous system and peripheral tissues in mammals contain a large number of
biologically active peptides and proteases that function as neurotransmitters or …

There is compelling evidence linking bradykinin (BK) with the pathophysiological processes
that accompany tissue damage and inflammation, especially the production of pare and …

Neurological disorders represent major health concerns in terms of comorbidity and
mortality worldwide. Despite a tremendous increase in our understanding of the …

Kinins are a group of peptides released in blood and tissues by the action of trypsin-like
endopeptidases, the kallikreins. A variety of stimuli have been shown to transform the …

The present review article regarding the kinin system-bradykinin is dealing with the
biological effects of the abovementioned entity mediated by specific B 1 and B 2 receptors …

We studied whether the components of the kallikrein-kinin system are present in the central
nervous system. We found that human cerebrospinal fluid (CSF) contains free kinins: 53±15 …

Kinins are among the most potent autacoids involved in inflammatory, vascular and pain
processes. These short-lived peptides, including bradykinin, kallidin and T-kinin, are …

In the previous edition of this section of the Handbook, the primary focus on kinins, with
regard to their relationships with the nervous system, was on their ability to stimulate …