Neuro-bone tissue engineering: multiple potential translational strategies between nerve and bone

Z Zhang, Z Hao, C Xian, Y Fang, B Cheng, J Wu, J Xia - Acta Biomaterialia, 2022 - Elsevier
Numerous tissue regeneration paradigms show evident neurological dependence, including
mammalian fingertip, skin, and bone regeneration. The mature skeleton is innervated by an …

[HTML][HTML] Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges

W Sun, B Ye, S Chen, L Zeng, H Lu, Y Wan, Q Gao… - Bone Research, 2023 - nature.com
The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal
cells. Peripheral nerve endings release neurogenic factors and sense skeletal signals …

[HTML][HTML] Engineering vascularized and innervated bone biomaterials for improved skeletal tissue regeneration

A Marrella, TY Lee, DH Lee, S Karuthedom, D Syla… - Materials Today, 2018 - Elsevier
Blood vessels and nerve fibers are distributed throughout the entirety of skeletal tissue, and
play important roles during bone development and fracture healing by supplying oxygen …

Crosstalk between bone and nerves within bone

QQ Wan, WP Qin, YX Ma, MJ Shen, J Li… - Advanced …, 2021 - Wiley Online Library
For the past two decades, the function of intrabony nerves on bone has been a subject of
intense research, while the function of bone on intrabony nerves is still hidden in the corner …

Bioprinted constructs that mimic the ossification center microenvironment for targeted innervation in bone regeneration

W Li, W Miao, Y Liu, T Wang, Y Zhang… - Advanced Functional …, 2022 - Wiley Online Library
Although great progress has been made in engineered bone tissues, delayed or ineffective
bone regeneration remains an issue due to the lack of neural network reconstruction in their …

Biomimetic neural scaffolds: a crucial step towards optimal peripheral nerve regeneration

J Du, H Chen, L Qing, X Yang, X Jia - Biomaterials science, 2018 - pubs.rsc.org
Peripheral nerve injury is a common disease that affects more than 20 million people in the
United States alone and remains a major burden to society. The current gold standard …

Neural tissue engineering: From bioactive scaffolds and in situ monitoring to regeneration

B Gong, X Zhang, AA Zahrani, W Gao, G Ma… - …, 2022 - Wiley Online Library
Peripheral nerve injury is a large‐scale problem that annually affects more than several
millions of people all over the world. It remains a great challenge to effectively repair nerve …

Construction of tissue engineered nerve grafts and their application in peripheral nerve regeneration

X Gu, F Ding, Y Yang, J Liu - Progress in neurobiology, 2011 - Elsevier
Surgical repair of severe peripheral nerve injuries represents not only a pressing medical
need, but also a great clinical challenge. Autologous nerve grafting remains a golden …

Bone tissue engineering: recent advances and challenges

AR Amini, CT Laurencin… - Critical Reviews™ in …, 2012 - dl.begellhouse.com
The worldwide incidence of bone disorders and conditions has trended steeply upward and
is expected to double by 2020, especially in populations where aging is coupled with …

Progress and perspectives of neural tissue engineering

X Gu - Frontiers of medicine, 2015 - Springer
Traumatic injuries to the nervous system lead to a common clinical problem with a quite high
incidence and affect the patient's quality of life. Based on a major challenge not yet …