Glucose as a potential key to fuel inflammation in rheumatoid arthritis

K Masuko - Nutrients, 2022 - mdpi.com
Glucose is the most important source of energy and homeostasis. Recent investigations are
clarifying that glucose metabolism might be altered in rheumatoid arthritis (RA), which would …

Glycolysis and rheumatoid arthritis

X Chang, C Wei - International journal of rheumatic diseases, 2011 - Wiley Online Library
Glucose metabolism not only provides energy for physical activity but also mediates a
variety of physiological processes through the formation of complex signalling networks …

The involvement of glucose and lipid metabolism alteration in rheumatoid arthritis and its clinical implication

TT Luo, YJ Wu, Q Yin, WG Chen… - Journal of Inflammation …, 2023 - Taylor & Francis
Obviously, immune cells like T cells and macrophages play a major role in rheumatoid
arthritis (RA). On one hand, the breakdown of immune homeostasis directly induces …

[HTML][HTML] Could glucose metabolism be a sweet target for RA therapy?

S Onuora - Nature Reviews Rheumatology, 2016 - nature.com
A new study shows that glucose metabolism is altered in rheumatoid arthritis fibroblast-like
synoviocytes (RA FLS), and that inhibition of glycolysis could suppress the pathogenic …

Critical role of glucose metabolism in rheumatoid arthritis fibroblast‐like synoviocytes

R Garcia‐Carbonell, AS Divakaruni… - Arthritis & …, 2016 - Wiley Online Library
Objective Up‐regulation of glucose metabolism has been implicated not only in tumor cell
growth but also in immune cells upon activation. However, little is known about the …

Fibroblast-like synoviocytes glucose metabolism as a therapeutic target in rheumatoid arthritis

PG De Oliveira, M Farinon, E Sanchez-Lopez… - Frontiers in …, 2019 - frontiersin.org
Metabolomic studies show that rheumatoid arthritis (RA) is associated with metabolic
disruption that may be therapeutically targetable. Among them, glucose metabolism and …

[PDF][PDF] Critical role of fibroblast-like synoviocytes glycolytic metabolism in rheumatoid arthritis

R Garcia-Carbonell, AS Divakaruni, A Lodi… - Arthritis …, 2016 - researchgate.net
Background: Glucose metabolism up-regulation has been implicated not only in tumor cell
growth but also in immune cells on activation. However, little is known about the metabolite …

Increase of aerobic glycolysis mediated by activated T helper cells drives synovial fibroblasts towards an inflammatory phenotype: new targets for therapy?

P Kvacskay, N Yao, JH Schnotz, R Scarpone… - Arthritis Research & …, 2021 - Springer
Background A dysregulated glucose metabolism in synovial fibroblasts (SF) has been
associated with their aggressive phenotype in rheumatoid arthritis (RA). Even though T …

Glycogen Metabolism and Rheumatoid Arthritis: The Role of Glycogen Synthase 1 in Regulation of Synovial Inflammation via Blocking AMP-Activated Protein Kinase …

M Shi, J Wang, Y Xiao, C Wang, Q Qiu, M Lao… - Frontiers in …, 2018 - frontiersin.org
Objective To investigate the role of glycogen metabolism in regulating rheumatoid fibroblast-
like synoviocyte (FLS)-mediated synovial inflammation and its underlying mechanism …

Impaired glucose metabolism underlies articular cartilage degeneration in osteoarthritis

K Li, X Ji, R Seeley, WC Lee, Y Shi, F Song… - The FASEB …, 2022 - Wiley Online Library
Osteoarthritis (OA) is the leading joint disease characterized by cartilage destruction and
loss of mobility. Accumulating evidence indicates that the incidence and severity of OA …