It has been suggested that dopaminergic mechanisms mediate relapse to drug-seeking
behavior and both D1-and D2-like receptor mechanisms have been implicated. In contrast to …

It has been suggested that activation of dopamine D1-like and D2-like receptors contribute
equally to the maintenance of drug self-administration. This study compared the contribution …

The sensitizing properties of drugs of abuse have been proposed to play an important role in
the persistence of drug seeking behavior. We decided to evaluate the temporal relationship …

BACKGROUND AND PURPOSE Animal models of drug‐seeking suggest that exposure to
cues associated with self‐administered drugs and drug primes might precipitate relapse via …

Rationale: The neurobiological mechanisms underlying the persistence of drug craving in
detoxified addicts are still poorly understood. Objective: The present study was designed to …

Prior exposure to amphetamine leads to sensitized locomotor responding to subsequent
injections and an enhanced predisposition to self-administer low doses of the drug. Because …

In brain regions that have been implicated in the reinstatement of drug-seeking, the
prelimbic cortex has emerged as a critical regulator of relapse behaviours. Here, the effects …

Methamphetamine is a strong and long-lasting stimulant that can be easily synthesized and
is effective when taken either orally, intravenously, or smoked asice'. Due to it's escalating …

We have previously reported that selective blockade of brain dopamine D 3 receptors by SB-
277011A significantly attenuates cocaine self-administration and cocaine-induced …

The involvement of dopamine D 1 receptor systems in the reinforcing properties of opiate
reward was studied by examining the effect of the dopamine D 1 antagonist SCH23390 on …