[HTML][HTML] Lipid droplet, a key player in host-parasite interactions

AL Vallochi, L Teixeira, KS Oliveira… - Frontiers in …, 2018 - frontiersin.org
Lipid droplets (lipid bodies, LDs) are dynamic organelles that have important roles in
regulating lipid metabolism, energy homeostasis, cell signaling, membrane trafficking, and …

Emerging roles for lipid droplets in immunity and host-pathogen interactions

HA Saka, R Valdivia - Annual review of cell and developmental …, 2012 - annualreviews.org
Lipid droplets (LDs) are neutral lipid storage organelles ubiquitous to eukaryotic cells. It is
increasingly recognized that LDs interact extensively with other organelles and that they …

Fat, fight, and beyond: The multiple roles of lipid droplets in infections and inflammation

FS Pereira-Dutra, L Teixeira… - Journal of leukocyte …, 2019 - academic.oup.com
Increased accumulation of cytoplasmic lipid droplets (LDs) in host nonadipose cells is
commonly observed in response to numerous infectious diseases, including bacterial …

Eukaryotic lipid droplets: metabolic hubs, and immune first responders

M Bosch, A Pol - Trends in Endocrinology & Metabolism, 2022 - cell.com
As major eukaryotic lipid storage organelles, lipid droplets (LDs) are metabolic hubs
coordinating energy flux and building block distribution. Infectious pathogens often promote …

Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense

M Bosch, M Sánchez-Álvarez, A Fajardo… - Science, 2020 - science.org
INTRODUCTION In all eukaryotic cells, lipid droplets (LDs) store and supply essential lipids
to produce signaling molecules, membrane building blocks, and metabolic energy. The LD …

Lipid droplets and the host–pathogen dynamic: FATal attraction?

M Bosch, MJ Sweet, RG Parton, A Pol - Journal of Cell Biology, 2021 - rupress.org
In the ongoing conflict between eukaryotic cells and pathogens, lipid droplets (LDs) emerge
as a choke point in the battle for nutrients. While many pathogens seek the lipids stored in …

Lipid droplets and lipid mediators in viral infection and immunity

EA Monson, AM Trenerry, JL Laws… - FEMS microbiology …, 2021 - academic.oup.com
Lipid droplets (LDs) contribute to key pathways important for the physiology and
pathophysiology of cells. In a homeostatic view, LDs regulate the storage of neutral lipids …

[HTML][HTML] Multifaceted Nature of Lipid Droplets in Viral Interactions and Pathogenesis

L Herrera-Moro Huitron, LA De Jesús-González… - Microorganisms, 2023 - mdpi.com
Once regarded as inert organelles with limited and ill-defined roles, lipid droplets (LDs) have
emerged as dynamic entities with multifaceted functions within the cell. Recent research has …

Lipid droplets as regulators of metabolism and immunity

DM Boucher, V Vijithakumar, M Ouimet - Immunometabolism, 2021 - journals.lww.com
A hallmark of sterile and nonsterile inflammation is the increased accumulation of
cytoplasmic lipid droplets (LDs) in non-adipose cells. LDs are ubiquitous organelles …

Lipid droplet hijacking by intracellular pathogens

P Roingeard, RCN Melo - Cellular Microbiology, 2017 - Wiley Online Library
Lipid droplets were long considered to be simple storage structures, but they have recently
been shown to be dynamic organelles involved in diverse biological processes, including …