Because nonopioid analgesics are much sought after, we computationally docked more
than 301 million virtual molecules against a validated pain target, the α2A-adrenergic …

Opiate drugs have potent analgesic and addictive properties. These drugs interact with
receptors that also mediate the response to endogenous opioid peptide ligands. However …

The α2 adrenergic receptors (α2ARs) are G protein-coupled receptors (GPCRs) that
respond to adrenaline and noradrenaline and couple to the Gi/o family of G proteins. α2ARs …

The α2A adrenergic receptor (α2AAR) is a G protein (heterotrimeric guanine nucleotide–
binding protein)–coupled receptor that mediates important physiological functions in …

Morphine, a powerful analgesic, and norepinephrine, the principal neurotransmitter of
sympathetic nerves, exert major inhibitory effects on both peripheral and brain neurons by …

The adenosine A1 receptor (A1R) is a promising therapeutic target for non-opioid analgesic
agents to treat neuropathic pain,. However, development of analgesic orthosteric A1R …

Morphine is an alkaloid from the opium poppy used to treat pain. The potentially lethal side
effects of morphine and related opioids—which include fatal respiratory depression—are …

Opioids represent widely prescribed and abused medications, although their signal
transduction mechanisms are not well understood. Here we present the 1.8 Å high …

Selective activation of the δ-opioid receptor (DOP) has great potential for the treatment of
chronic pain, benefitting from ancillary anxiolytic and antidepressant-like effects. Moreover …

The opioid receptor family comprises three members, the µ-, δ-and κ-opioid receptors, which
respond to classical opioid alkaloids such as morphine and heroin as well as to …