Results DILIN's consensus expert opinion diagnosed 1 case as definite (> 95% likelihood), 4
cases as highly likely (75%–95%), and 2 cases as probable (50%–74%). All patients …

Objective Oxaliplatin, a component of chemotherapy for colorectal carcinoma liver
metastases, can result in hepatic sinusoidal injury; rarely, the injury is fatal. The …

In 2004, Rubbia-Brandt reported the association between oxaliplatin-based chemotherapy
and sinusoidal dilatation corresponding to sinusoidal obstruction syndrome (SOS). 1 Since …

A 40 years old male with colorectal cancer, with an unbalanced hypercaloric diet, attempted,
on his own initiative, to gain weight, without nutritional follow-up, during chemotherapy …

Chemotherapy is a potential cause of focal and diffuse hepatobiliary lesions. Many of these
lesions may be demonstrated on imaging, especially computed tomography and MRI. Some …

Treating patients undergoing chemotherapy who display findings of liver toxicity, requires a
solid understanding of these medications. It is important for any clinician to have an index of …

Chemotherapy-associated liver injuries (CALI) were the focus of several research studies
some years ago when they were associated with modern treatments for colorectal …

Question: A 37-year-old woman presented with multiple liver lesions recently revealed by
imaging studies. The patient's history is remarkable for rectal cancer diagnosed 4 years …

Oxaliplatin-based chemotherapy is widely used for advanced colorectal cancer treatment,
but it occasionally induces liver injury that is characterized histologically by sinusoidal …

Discussion: DILI is one of the most common causes of ALF. Doxorubicin's mechanism of
action in disrupting major enzymes in the antioxidant system causes oxidative stress and …