A strategy to achieve regular and long lasting organ and tissue allografts without using
immunosuppressants and/or irradiation has been established for mice. One hundred …

Publisher Summary This chapter focuses on primarily renal transplantation in man. In the
process of transplanting livers, kidneys, and skin in the human the development of new …

The long-term success of organ transplantation is limited by complications resulting from
consistent nonspecific immunosuppression. Induction of stable, donor-specific tolerance …

The use of allogeneic bone marrow transplantation as a means of inducing donor-specific
tolerance across MHC barriers could provide an immunologically specific conditioning …

BALB/c mice were treated with fractionated high dose (3,400 rads) total lymphoid irradiation
(TLI), and given semiallogeneic (BALB/cx C57BL/Ka) or allogeneic (C57BL/Ka) bone …

The events following organ transplantation require a reciprocal cell interaction which
includes both the conventional host-versus-graft reaction and a graft-versus-host …

Subject: N28150*-Life Sciences-Biochemistry, Physiology, & Molecular Biology-
Immunology; N28620-Life Sciences-Radiation Effects on Animals-Vertebrates; …

The development of safe methods for inducing donor-specific tolerance across xenogeneic
barriers could potentially relieve the critical shortage of allograft donors that currently limits …

Liver allografts in pigs and in rats elicit a substantial cellular immune response that can
resolve spontaneously with the induction of donor-specific systemic tolerance. Self-limiting …

Histoincompatible-complete radiation chimeras, after resolving acute graft-versus-host
disease (GVHD), establish specific tolerance to host and donor alloantigens. This tolerance …