Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation
Recent advances highlight a pivotal role for cellular metabolism in programming immune
responses. Here, we demonstrate that cell-autonomous generation of nicotinamide adenine …
responses. Here, we demonstrate that cell-autonomous generation of nicotinamide adenine …
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages
Declining tissue nicotinamide adenine dinucleotide (NAD) levels are linked to ageing and its
associated diseases. However, the mechanism for this decline is unclear. Here, we show …
associated diseases. However, the mechanism for this decline is unclear. Here, we show …
[HTML][HTML] Why NAD+ declines during aging: it's destroyed
MB Schultz, DA Sinclair - Cell metabolism, 2016 - cell.com
Why NAD+ Declines during Aging: It’s Destroyed: Cell Metabolism Skip to Main Content
Advertisement Cell Metabolism This journal offers authors two options (open access or …
Advertisement Cell Metabolism This journal offers authors two options (open access or …
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels
CCS Chini, TR Peclat, GM Warner, S Kashyap… - Nature …, 2020 - nature.com
Decreased NAD+ levels have been shown to contribute to metabolic dysfunction during
aging. NAD+ decline can be partially prevented by knockout of the enzyme CD38. However …
aging. NAD+ decline can be partially prevented by knockout of the enzyme CD38. However …
NAD+ metabolism and its roles in cellular processes during ageing
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …
[HTML][HTML] NAD+ flux is maintained in aged mice despite lower tissue concentrations
NAD+ is an essential coenzyme for all living cells. NAD+ concentrations decline with age,
but whether this reflects impaired production or accelerated consumption remains unclear …
but whether this reflects impaired production or accelerated consumption remains unclear …
NAD+ in aging: molecular mechanisms and translational implications
The coenzyme NAD+ is critical in cellular bioenergetics and adaptive stress responses. Its
depletion has emerged as a fundamental feature of aging that may predispose to a wide …
depletion has emerged as a fundamental feature of aging that may predispose to a wide …
[HTML][HTML] Evolving concepts in NAD+ metabolism
CCS Chini, JD Zeidler, S Kashyap, G Warner, EN Chini - Cell metabolism, 2021 - cell.com
Summary NAD (H) and NADP (H) have traditionally been viewed as co-factors (or co-
enzymes) involved in a myriad of oxidation-reduction reactions including the electron …
enzymes) involved in a myriad of oxidation-reduction reactions including the electron …
Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage
AM Cameron, A Castoldi, DE Sanin… - Nature …, 2019 - nature.com
The adoption of Warburg metabolism is critical for the activation of macrophages in
response to lipopolysaccharide. Macrophages stimulated with lipopolysaccharide increase …
response to lipopolysaccharide. Macrophages stimulated with lipopolysaccharide increase …
[HTML][HTML] The balance between NAD+ biosynthesis and consumption in ageing
Ø Strømland, J Diab, E Ferrario, LJ Sverkeli… - Mechanisms of Ageing …, 2021 - Elsevier
Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme in redox reactions. NAD+ is
also important in cellular signalling as it is consumed by PARPs, SARM1, sirtuins and CD38 …
also important in cellular signalling as it is consumed by PARPs, SARM1, sirtuins and CD38 …