Purpose Some recent studies have suggested a relationship between cardiac dose and
mortality in non-small cell lung cancer (NSCLC), but others have reported conflicting data …

Background: Radiotherapy-associated cardiac toxicity studies in patients with locally
advanced non–small cell lung cancer (NSCLC) have been limited by small sample size and …

Background: The aim of this study was to investigate the link between heart dose and overall
survival, the link between heart dose and cardiac events and whether radiation-induced …

Purpose Mean heart dose (MHD) over 10 Gy and left anterior descending (LAD) coronary
artery volume (V) receiving 15 Gy (V15Gy) greater than 10% can significantly increase the …

Purpose The significance of radiotherapy (RT)–associated cardiac injury for stage III non–
small-cell lung cancer (NSCLC) is unclear, but higher heart doses were associated with …

Introduction In the randomized trial of standard-versus high-dose chemoradiotherapy for
locally advanced (LA) NSCLC (Radiation Therapy Oncology Group 0617), overall survival …

Background Higher cardiac radiotherapy (RT) doses when treating lung cancer are
associated with worse overall survival (OS), although the direct association between cardiac …

Background and purpose To determine whether the impact of heart dose on early overall
survival (OS) reported in RTOG 0617 could be confirmed in an independent cohort …

Background To maximize the likelihood of positive outcome in non-small-cell lung cancer
(NSCLC) survivors, potential benefits of treatment modalities have to be weighed against the …

Background Radiation-induced cardiotoxicity poses a significant challenge in lung cancer
management because of the close anatomical proximity of the heart to the lungs …