LIMB muscles develop from cells that migrate from the somites1, 2. The signal that induces
migration of myogenic precursor cells to the limb emanates from the mesenchyme of the …

Hepatocyte growth factor/scatter factor (HGF/SF) stimulates proliferation, dissociation,
migration and morphogenesis of cells in culture. To investigate a possible role for HGF/SF …

BASAL lamina is a sheet of extracellular matrix that separates cells into topologically distinct
groups during morphogenesis and is thought to form a barrier to cell migration. We have …

Pax3 is a transcription factor whose expression has been used as a marker of myogenic
precursor cells arising in the lateral somite destined to migrate to and populate the limb …

The initiating event in the migration of myogenic cells to the limb buds is an
epitheliomesenchymal transformation of cells located at the lateral edge of the …

The skeletal muscles of the limbs develop from myogenic progenitors that originate in the
paraxial mesoderm and migrate intothe limb-bud mesenchyme. Among the genes known to …

MICE that have mutations in both myogenic transcription factors Myf-5 and MyoD totally lack
skeletal muscle fibres and their precursor myoblasts1, whereas with either mutation alone …

MYOGENIN is a member of the basic helix-loop-helix (bHLH) gene family and converts
multipotential mesodermal cells to myoblasts1–4. The four members of the myoD family …

During vertebrate embryogenesis, myogenic precursor cells of limb muscles delaminate
from the ventro-lateral edge of the somitic dermomyotome and migrate to the limb buds …

Abstract THE protein XTC-MIF, a Xenopus homologue of activin A and a potent mesoderm-
inducing factor1, can induce responding animal pole explants to form several different cell …