Sexual dysfunction is prominent in Major Depressive Disorder (MDD) and affects women
with depression more than men. Patients with MDD relative to healthy controls have lower …

The serotonergic system integrates sex steroid information and plays a central role in mood
and stress regulation, cognition, appetite and sleep. This interplay may be critical for …

Background Major depressive disorder (MDD) is closely associated with sexual dysfunction,
which may worsen during treatment with selective serotonin reuptake inhibitors (SSRIs) due …

1. Stahl SM. Circuits of sexual desire in hypoactive sexual desire disorder. J Clin Psychiatry.
2010; 71 (5): 518–519. doi: 10.4088/JCP. 10bs06115whi PubMed 2. Pfaus JG. Pathways of …

Background The neurobiology of sexual response is driven in part by dopamine and
serotonin—the former modulating excitatory pathways and the latter regulating inhibitory …

Sexual dysfunction related to treatment with selective serotonin reuptake inhibitors (SSRIs)
is a common reason for discontinuation of otherwise effective antidepressant treatment …

Introduction Among other causes, low sexual desire in women may result from dysfunctional
activation of sexual inhibition mechanisms during exposure to sex. Administration of …

Introduction To date, few studies have specifically investigated the genetic determinants of
antidepressant-induced sexual dysfunction (SD). Aim The aim of this prospective study was …

Background Hormonal contraceptive (HC) use has been associated with an increased risk
of developing a depressive episode. This might be related to HC's effect on the serotonergic …

The occurrence of sexual side-effects from antidepressants is thought to be mediated
through serotonin 2A (5HT2A) receptors. It is currently unknown if functional polymorphisms …