Abstract Structure‐based ligand design in medicinal chemistry and crop protection relies on
the identification and quantification of weak noncovalent interactions and understanding the …

The understanding of noncovalent interactions in protein–ligand complexes is essential in
modern biochemistry and should contribute toward the discovery of new drugs. In the …

Noncovalent interactions constitute the basis for information transfer between molecules in
living systems as well as in synthetic supramolecular structures. Despite ever more accurate …

This review describes a multidimensional treatment of molecular recognition phenomena
involving aromatic rings in chemical and biological systems. It summarizes new results …

Why does experimental determination of the structure of drug–receptor complexes so often
result in surprises? The importance of hydrogen bonding and hydrophobic interactions in …

Forces to reckon with: Supramolecular complexes, such as the one shown, are normally
based on a combination of different interactions such as ion pairing, hydrogen bonds, and …

Molecular recognition in biological systems relies on the existence of specific attractive
interactions between two partner molecules. Structure-based drug design seeks to identify …

Abstract Structure‐based design usually focuses upon the optimization of ligand affinity.
However, successful drug design also requires the optimization of many other properties …

The design of high‐affinity synthetic host–guest complexes is of paramount importance
because they are key elements in constructing unprecedented supramolecular assemblies …

Attractive chlorine: Noncovalent interactions between chlorine or bromine atoms and
aromatic rings in proteins open up a new method for the manipulation of molecular …