Hepatocellular carcinoma (HCC) is a lethal disease, and recurrence and metastasis are the
major causes of death in HCC patients. Cancer-associated fibroblasts (CAFs), a major …

The tumor microenvironment (TME) is a complex multicellular functional compartment that
includes fibroblasts, myofibroblasts, endothelial cells, immune cells, and extracellular matrix …

Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide and the
fourth leading cause of cancer-related death globally. Tumor cells recruit and remodel …

The hepatic stellate cells in the liver are stimulated sustainably by chronic injury of the
hepatocytes, activating myofibroblasts, which produce abundant collagen. Myofibroblasts …

Primary liver cancer (PLC) includes hepatocellular carcinoma and intrahepatic
cholangiocarcinoma and is the sixth most common cancer worldwide with poor prognosis …

Invasion and metastasis are the main reasons for the high mortality of liver cancer, which
involve the interaction of tumor stromal cells and malignant cells. Cancer-associated …

Background & Aims Cancer-associated fibroblasts (CAFs) play a key role in the cancer
process, but the research progress is hampered by the paucity of preclinical models that are …

Background and Aims Cancer‐associated fibroblasts (CAFs) are key players in multicellular,
stromal‐dependent alterations leading to HCC pathogenesis. However, the intricate …

Background Cancer-associated fibroblasts (CAFs) are involved in tumor growth,
angiogenesis, metastasis, and resistance to therapy. We sought to explore the CAFs …

Hepatocellular carcinoma (HCC) is a significant cause of cancer-related mortality owing to
resistance to traditional treatments and tumor recurrence after therapy, which leads to poor …