[图书][B] Elucidation of the Function and Regulation of STAT3 during IFNγ-and TNFα-induced Muscle Wasting
JFM Ma - 2017 - search.proquest.com
Skeletal muscle is a highly adaptable tissue capable of responding to stimuli. In the late-
stages of chronic disease such as kidney disease and cancer, a condition called cachexia …
stages of chronic disease such as kidney disease and cancer, a condition called cachexia …
STAT 3 promotes IFN γ/TNF α‐induced muscle wasting in an NF‐κB‐dependent and IL‐6‐independent manner
JF Ma, BJ Sanchez, DT Hall, AMK Tremblay… - EMBO molecular …, 2017 - embopress.org
Cachexia is a debilitating syndrome characterized by involuntary muscle wasting that is
triggered at the late stage of many cancers. While the multifactorial nature of this syndrome …
triggered at the late stage of many cancers. While the multifactorial nature of this syndrome …
JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia
A Bonetto, T Aydogdu, X Jin, Z Zhang… - American Journal …, 2012 - journals.physiology.org
Cachexia, the metabolic dysregulation leading to sustained loss of muscle and adipose
tissue, is a devastating complication of cancer and other chronic diseases. Interleukin-6 and …
tissue, is a devastating complication of cancer and other chronic diseases. Interleukin-6 and …
[PDF][PDF] STAT3 promotes IFNc/TNFa-induced muscle wasting in an NF-jB-dependent and IL-6-independent manner
JF Ma, BJ Sanchez, DT Hall, AMK Tremblay… - academia.edu
Cachexia is a debilitating syndrome characterized by involuntary muscle wasting that is
triggered at the late stage of many cancers. While the multifactorial nature of this syndrome …
triggered at the late stage of many cancers. While the multifactorial nature of this syndrome …
[PDF][PDF] STAT3 Regulation of Skeletal Muscle Wasting in Cancer Cachexia
T Aydogdu - 2010 - scholarship.miami.edu
Cachexia is a highly complex syndrome identified by metabolic, hormonal and cytokine-
related abnormalities, but can be shortly characterized as accelerated skeletal muscle and …
related abnormalities, but can be shortly characterized as accelerated skeletal muscle and …
[HTML][HTML] STAT3 activation in skeletal muscle links muscle wasting and the acute phase response in cancer cachexia
A Bonetto, T Aydogdu, N Kunzevitzky, DC Guttridge… - PloS one, 2011 - journals.plos.org
Background Cachexia, or weight loss despite adequate nutrition, significantly impairs quality
of life and response to therapy in cancer patients. In cancer patients, skeletal muscle …
of life and response to therapy in cancer patients. In cancer patients, skeletal muscle …
[HTML][HTML] eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways
Cachexia is a deadly muscle wasting syndrome that arises under conditions linked to
chronic inflammation, such as cancer. Cytokines, including interferon γ (IFNγ), tumor …
chronic inflammation, such as cancer. Cytokines, including interferon γ (IFNγ), tumor …
IFN-γ does not mimic the catabolic effects of TNF-α
MA Smith, JS Moylan, JD Smith… - American Journal of …, 2007 - journals.physiology.org
Cachexia is common in chronic inflammatory diseases and is attributed, in part, to an
elevation of circulating proinflammatory cytokines. TNF-α is the prototype in this category …
elevation of circulating proinflammatory cytokines. TNF-α is the prototype in this category …
Stat3 regulation of muscle wasting in cancer cachexia
L Koniaris, T Aydogdu, S Guo, Z Zhang, X Jin, L Puzis… - Cancer Research, 2008 - AACR
Abstract 868 BACKGROUND: Cachexia, or progressive wasting of adipose tissue and
skeletal muscle, is a devastating condition afflicting about half of all cancer patients …
skeletal muscle, is a devastating condition afflicting about half of all cancer patients …
Interferon-γ (IFN-γ) does not mimic the catabolic effects of tumor necrosis factor-α (TNF-α)
Cachexia is common in chronic inflammatory diseases and is attributed, in part, to elevation
of circulating pro-inflammatory cytokines. TNF-α is the prototype in this category. IFN-γ is …
of circulating pro-inflammatory cytokines. TNF-α is the prototype in this category. IFN-γ is …